29. hyalinosis Flashcards
what is hyalinosis
hyaline degeneration
staining
stained homogenously pink with eosin in histopathological section
physiological hyalinosis
in the blood vessels of uterus during involution
pathologicla hyalinosis locations
CT origin, cellular origin, hematogenous origin
causes of extracellular hyalinosis of connective tissues
often immunopathological, there are some other causes too eg tissue acidosis
extracellular hyalinosis how does it happen
connective tissue matrix is swollen, homogenously stained
forms of extracellular hyalinosis due to immunopathologic processes
systemic and local
when would we see extracellular hyalinosis caused by tissue acidosis
in scars
staining reaction of extracellular hyaline in millons and xantoproteic tests
positive
staining reaction of extracellular hyaline in acidic stains
strongly acidophilic, van giesons brilliant red
staining reaction of extracellular hyaline in acids and alkalis
not soluble
when might we see intracellular hyalinosis
in epithelial cells, following cell destruction and in hyperactive plasma cells
types of intracellular hyalinosis
intact cell, autophagic vacuole, mallory body, councilman body
where would you see hematogenous hyalinosis
in the wall of the blood vessels
forms of hematogenous hyalinosis
hyaline membrane, hyaline fibrin, hyaline cylinder, corpus amylaceum, caoutchouc hyaline
macroscopic changes in extracellular hyalinosis
visible only in severe cases, smaller or larger swelling of th affected area, diagnosis must be confirmed by histopathology
macroscopic changes in intracellular hyalinosis
recognised in histological section
macroscopic changes in haematogenous hyalinosis
in some cases visible during dissection bus usually seen with histopathology
fibrinoid necrosis where would you see it
in the wall of blood vessels, in connectiev tissue
fibrinoid necorsis mechanim of action
deposition of homogenous substance + necrosis -> basic characteristic change
fibrinoid necrosis in blood vessels explain
serum accumulated in media - affected area necrotises - lesions appear in nodular form in blood vessles, changes cicumscribed, irregular and uneven
fibrinoid necrosis in connective tissue
collagen fibers swell and necrotise - around the necrotised tissue, reactive inflammation occurs
causes of fibrinoid necrosis
immune processed eg polyarteritis nodosa, rheumatoid arthritis
