29. hyalinosis

Question 1

what is hyalinosis

Answer 1

hyaline degeneration

Question 2

staining

Answer 2

stained homogenously pink with eosin in histopathological section

Question 3

physiological hyalinosis

Answer 3

in the blood vessels of uterus during involution

Question 4

pathologicla hyalinosis locations

Answer 4

CT origin, cellular origin, hematogenous origin

Question 5

causes of extracellular hyalinosis of connective tissues

Answer 5

often immunopathological, there are some other causes too eg tissue acidosis

Question 6

extracellular hyalinosis how does it happen

Answer 6

connective tissue matrix is swollen, homogenously stained

Question 7

forms of extracellular hyalinosis due to immunopathologic processes

Answer 7

systemic and local

Question 8

when would we see extracellular hyalinosis caused by tissue acidosis

Answer 8

in scars

Question 9

staining reaction of extracellular hyaline in millons and xantoproteic tests

Answer 9

positive

Question 10

staining reaction of extracellular hyaline in acidic stains

Answer 10

strongly acidophilic, van giesons brilliant red

Question 11

staining reaction of extracellular hyaline in acids and alkalis

Answer 11

not soluble

Question 12

when might we see intracellular hyalinosis

Answer 12

in epithelial cells, following cell destruction and in hyperactive plasma cells

Question 13

types of intracellular hyalinosis

Answer 13

intact cell, autophagic vacuole, mallory body, councilman body

Question 14

where would you see hematogenous hyalinosis

Answer 14

in the wall of the blood vessels

Question 15

forms of hematogenous hyalinosis

Answer 15

hyaline membrane, hyaline fibrin, hyaline cylinder, corpus amylaceum, caoutchouc hyaline

Question 16

macroscopic changes in extracellular hyalinosis

Answer 16

visible only in severe cases, smaller or larger swelling of th affected area, diagnosis must be confirmed by histopathology

Question 17

macroscopic changes in intracellular hyalinosis

Answer 17

recognised in histological section

Question 18

macroscopic changes in haematogenous hyalinosis

Answer 18

in some cases visible during dissection bus usually seen with histopathology

Question 19

fibrinoid necrosis where would you see it

Answer 19

in the wall of blood vessels, in connectiev tissue

Question 20

fibrinoid necorsis mechanim of action

Answer 20

deposition of homogenous substance + necrosis -> basic characteristic change

Question 21

fibrinoid necrosis in blood vessels explain

Answer 21

serum accumulated in media - affected area necrotises - lesions appear in nodular form in blood vessles, changes cicumscribed, irregular and uneven

Question 22

fibrinoid necrosis in connective tissue

Answer 22

collagen fibers swell and necrotise - around the necrotised tissue, reactive inflammation occurs

Question 23

causes of fibrinoid necrosis

Answer 23

immune processed eg polyarteritis nodosa, rheumatoid arthritis