25. disturbances of carbohydrate metabolism Flashcards
what is glycogen
storage form of glucose
where is glycogen normally deposited
- hepatocytes
- myocytes
- renal tubular cells
fixation of glycogen
10% buff formaline at 4degrees
stainings of glycogen
- PAS
- PAS and amylase pretreatment
- bests carmine - red
reasons for increased glycogen production and or accumulation
- overfeeding
- increased activity
- glycogen storage diseases
examples of glycogen storage diseases
- enzymeopathies
- inhibited glycolysis
- predilection sites
- gierkes disease
whats gierkes disease
- enzymeopathy
- lack of glucose-6-phosphatase
- hypoglycaemia at starvation
reasons for decreased level of glycogen
decreased production, increased mobilisation
reasons for decreased glycogen production
- toxic chemicals
- bacterial toxins
- mycotoxins
reasons for increased mobilisation of glycogen
- starvation
- baby pig disease
- cold
- increased metabolism
what is diabetes mellitus
cluster of metabolic disorders associated with the relative or absolute lack of insulin, resulting in persistant hyperglycaemia and consequential glucosuria
two major types of DM
- type 1 -insulin dependant DM
- type 2 - non insulin dependant DM
whats type 1 diabetes
primary dysfunction of sinsulin secretion -> good response to insulin therapy
whats type 2 diabetes
when pancreas doesnt produce enough to maintain normal blood glucose or body unable to use insulin thats produced -> insulin resistance, insulin therapy not good
type 2 is mainly seen in what kind of animals
cats, obese animals, older animals