(28) Pituitary Hormones Continued

Question 1

(Pathophysiology of ADH)

1. Cations, drugs and hormones can influence the action of ADH causing what?
2. What are the treatments (2 of these)?

Answer 1

1. polyuria

(then read through slide - she says to just think about it)

2. vasopressin analog, desmopressin for central DI (diabetes insipidus)

Question 2

(Oxytocin)

1. how many aa peptide?
2. secreted within what and from what?

Answer 2

1. 9
2. secreted within brain and from ovaries and testes

Question 3

(regulation of oxytocin secretion)

1. most important stimulus is what? What do these singals impinge on?

Answer 3

1. suckling - goes to brain via spinal reflex arc; oxytocin secreting neurons, leading to release of oxytocin

(other stimulants - sight, sound or smell of infant, cervical dilation)

Question 4

(Actions of oxytocin)

1. major action?
2. milk initially secreted into what? these are surrounded by what? what targets these? oxytocin causes what?

Answer 4

1. milk ejection
2. alveoli; smooth muscle (myoepithelail) cells; oxytocin; contraction

Question 5

(Actions of oxytocin)

(uterine contraction)

1. late in gestation there is an increase in what on uterine smooth muscle?
2. Oxytocin is released during labor when the fetus stimulates the what?

Answer 5

1. oxytocin receptors
2. cervix and vagina

Question 6

(Oxytocin)

1. involved in what kind of behavior?
2. do non-lactating females respond in the same way?

Answer 6

1. maternal behavior/attachment
2. no

fuck it - just read this

Question 7

(Control of oxytocin secretion)

1. Acute stress inhibit or stimulate oxytocin release?
2. Oxytocin are repressed by what things that are released from the adrenal gland in response to many types of stress (including fright)

Answer 7

1. inhibit
2. catecholeamines

Question 8

(Steroidal Control of Oxytocin Secretion)

1. Both the production of oxytocin and the response to oxytocin are modulated by what?
2. The burst of oxytocin released at birth may be triggered in part by what? but also because of what?
3. Increasing concentrations of circulating estrogen late in gestation cause increase in synthesis of what?

Answer 8

1. sex steroids
2. cervical and vaginal stimulation of fetus; abruptly declining concentrations of progesterone
3. uterine (myometrial) oxytocin receptors

Question 9

Role of oxytocin in male?

Answer 9

facilitate sperm transport in male and femal (present in seminal fluid)