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002 - 6130 - Vet Phys > (27-2) Pituitary Hormones Continued > Flashcards

(27-2) Pituitary Hormones Continued Flashcards

1
Q

(Prolactin)

  1. secreted as what?
  2. major target organ?
  3. receptors on most tissues?
  4. synthesized/secreted by many or one tissues?
  5. role in transition to sexual maturity in rats
  6. required for pregnancy maintenance in dogs, rodents, and skunks
A
  1. prohormone
  2. mammary gland
  3. yes
  4. many
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2
Q

(Prolactin)

  1. influence what kind of behaviors?
  2. suppresses what?
  3. growth support of what?
  4. stimulatino of what?
  5. marked effects on what?
A
  1. parenting
  2. lipid storage
  3. pancreatic islets
  4. insulin
  5. immune function
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3
Q

(Prolactin Stimulation)

activation - TRH

inhibition - Doopamine

A
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4
Q

(Prolactin Control)

  1. Tonic suppression of Prl by what?
  2. What is main inhibiting factor? another? feedback?
  3. What are stimulating factors?
  4. What is secreted during late pregnancy that stimulates Prl? prepare for what?
A
  1. Hypothalamus
  2. dopamine; somatostatin; negative
  3. TRH, GnRH, stress, sucklking
  4. estrogens; parturition
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5
Q

(Where does dopamine come from)

  1. what in the HT?
  2. some dopaminergic neurons in the what that connect via what?
  3. Non lactotroph cells of the AP secrete a small amount of DP that diffuses to the lactotrophs and inhbits prl secretion by a what mechanism?
A
  1. dopaminergic neurons in HT
  2. posterior pituitary; short portal veins
  3. paracrine
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6
Q

(Prolactin: Major effects)

  1. What does it do?
A
  1. mammary gland development, milk production and reproduction

just read these

pay extra atention to GnRH on end of list (need to resources for developing milk and not developing fetus - won’t get preggers while lactating)

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7
Q

(SHIFTING TO POSTERIOR PITUITARY)

learn this

A
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8
Q

only differ by a couple AA’s

A
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9
Q

learn this (figure from text book)

A
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10
Q

(Antidiuretic Hormone aka ADH aka Vasopressin)

  1. ADH is a how many AA peptide?
  2. Within hypothalamic neurons, the hormone is pacakged in secretory vesicles with a carrier protein called what? Both are released up what?
  3. Major effect in on what (regulates what)?
  4. Major role?
A
  1. 9 AA
  2. neurophysin; hormone secretion
  3. kidney (fulid osmolarity)
  4. water conservation
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11
Q

(Antidiuretic Hormone aka ADH aka Vasopressin)

  1. diuretic does what?

(Effects on Vascular systems of ADH)

  1. high conc of ADH cause widespread constriction or opposite of arterioles? leads to what?
A
  1. increases rate of urine formation
  2. constriction; increased arterial pressure (why vasopressin was coined)
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12
Q

(Actions of ADH)

  1. ADH binds to receptors in what of kidny?
  2. promotes what?
  3. In absence of ADH, kidney tubules are what?
  4. big thing it does then?
A
  1. distal or collecting tubules of kidney
  2. reabsorption of water back into circulation
  3. impermeable to urine
  4. increase in water permeability
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13
Q

(Actions of Antidiuretic Hormone)

  1. ADH receptor is coupled to a IP#/Ca2+ messenger system which results in what?
  2. Increae in vascular resistance causes increase in what?
  3. When is ADH released?
A
  1. contraction of vascular smooth muscle (constriction of arterioles and increased peripheral resistance)
  2. blood pressure
  3. when dehydrated (increased osmolarity)
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14
Q

(ADH)

  1. What are inserted into membranes of kidney tubules to move water?
A
  1. aquaporins
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15
Q

(control of ADH)

  1. main variable which regulates ADH is what?
  2. osmolarity sensed by what?
  3. What stimulate secretion of ADH?
  4. When osmolarity is below a threshold, osmoreceptors are what? What is suppressed?
A
  1. plasma osmolarity
  2. osmoreceptors (HT neurons)
  3. neurons
  4. osmoreceptors are not active - ADH is suppressed

look at this

ECF = extracellular fluid

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16
Q

(pathophysiology of ADH)

  1. What is it called when there is a definiency in ADH secretion from posterior pituitary?
  2. occurence in catas and gods?
  3. what is it called wh kidney is unable to respond to ADH? ADH concentrations high or low? typically due to what?
  4. signs (of both)?
A
  1. Diabete insipidus (large amts of dilute urine and body fluid become concentrated)
  2. rare
  3. nephrogenic diabetes insipidus; high (due to simulation by icreased serum osmolarity); renal disease
  4. excessive thirst; PU/PD

002 - 6130 - Vet Phys (28 decks)

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