274b hodgkin lymphoma

Question 1

cell markers
CD 20
CD3
TDT

Answer 1

CD20 = b cell

CD3 = t cell (cytoplasm in immature, surface in mature T cells) plus CD2,3,5,7

TDT = marker of lymphoblastic leukaemia/lymphoma (young cells); negative = peripheral/more mature T cell lymphoma

Question 2

adult t-cell lymphoma - who gets it?

Answer 2

adults - long latency

Question 3

adult t-cell lymphoma - what causes it?

Answer 3

HTLV1 (w/ IV drug use or breast milk) –> CD4+ T cells lose CD7 marker

Question 4

adult t-cell lymphoma - presentation? where? nuclei appearance?

Answer 4

cutaneous lesions, lytic bone lesions, hypercalcemia

Japan, West Africa, Caribbean

flower shaped nuclei in T cells

Question 5

Mycosis fungoides/Sezary syndrome - what is it?

Answer 5

neoplasm of mature T-cells –> CD4+

Question 6

Mycosis fungoides/Sezary syndrome - who gets it?

Answer 6

adults

Question 7

Mycosis fungoides/Sezary syndrome - presentation? disease outcome?

Answer 7

cutaneous patches, plaques, tumors –> spread to lymph nodes and viscera

indolent

Question 8

Hodgkin Lymphoma - cell origin?

Answer 8

B cell

Question 9

Hodgkin Lymphoma - cell?

Answer 9

reed-sternberg cell

2 halves as mirror images –> owl eye

CD15+, CD30+

Question 10

Hodgkin Lymphoma - classification?

Answer 10

nodular lymphocyte predominant –> good prognosis; 5%; popcorn cells, not reed-sternberg

classical - 95%; bimodal distro; mediastinal mass; nodular sclerosing form is most common

Question 11

Hodgkin Lymphoma - which has best prognosis?

Answer 11

nodular lymphocyte