254b breast cancer II

Question 1

BRCA genes - general type of gene? gene product? associated tumors? pentrenance?

Answer 1

tumor suppressor gene (both must be lost for cancer) –> DNA repair protein

breast and ovarian cancer - higher rates but not 100%

autosomal (inherited from mother and father)

incomplete pentrenance

Question 2

Li-Fraumeni syndrome - general type of gene? gene product? associated cancers?

Answer 2

tumor suppressor gene (both must be lost); P53 –> transcription factor for p21 (blocks G1->S)

most human cancers - breast, bone, brain, soft tissue, ect (Li-Fraumeni syndrome)