241b preventative oncology Flashcards
1
Q
how big do cancers have to be in order to cause symptoms?
A
1 cm - takes a long time to get that big; has thousands of molecular abnormalities –> end of disease and drugs only work at a single target
2
Q
lynch syndrome (HNPCC) mutation
A
DNA mismatch repair defect
3
Q
FAP mutation
A
APC gene - thousands of polyps in colon
4
Q
field carcinogensis
A
whole colon (for example) is at risk for developing multiple cancers
5
Q
tamoxifen/raloxifene
A
SERM - antagonists at breast
6
Q
lung cancer risk
A
smoking
asbestos
radon in ground
particulate matter
7
Q
helical low-dose CT (LDCT)
A
early detection
decreases death from lung cancer by 20%
8
Q
prostate cancer incidence
A
incidence = age - 10 = %
