235b viral oncogenes

Question 1

EBV
virus type? genetic material?
disease?
associated cancer?

Answer 1

Herpesvirus, DNA

causes mononucleosis

Burkitt lymphoma (8:14, MYC and Ig translocation in B-cells, starry sky pattern in histo, think HIV)
hodgkin lymphoma
nasopharyngeal carcinoma
CNS lymphoma + oral hairy leukoplakia in immunocompromised

Question 2

HBV, HCV
virus types? genetic material? spread?
associated cancer?
vaccine?
carrier?

Answer 2

HBV= hepadnavirus; DNA –> integrates into host genome + chronic inflammation –> cancer; sexual

HCV=flavivirus, RNA, doesn’t integrate but causes chronic inflammation –> cancer; blood

HCC

vaccine for HBV

HBV = Babies become carrier
HCV= yes, integrates into genome

Question 3

HHV-8 (kaposi sarcoma - associated herpesvirus)
virus type? genetic material?
associated cancer?

Answer 3

herpesvirus, DNA

kaposi sarcoma
body cavity B-cell lymphoma

Question 4

HPV
virus type? genetic material?
virus products?
disease?
associated cancer?

Answer 4

papillomavirus, DNA virus

E6–I p53
E7–I Rb

causes condylomata acuminata (6, 11)

cervical and penile/anal carcinoma (16, 18)
head and neck/throat cancer

Question 5

H Pylori

associated cancer?

Answer 5

gastric adenocarcinoma and MALT lymphoma

Question 6

HTLV-1
virus type? genetic material?
associated cancer?

Answer 6

Retrovirus, RNA virus

adult t-cell leukemia/lymphoma

Question 7

liver fluke (clonorchis sinensis)
associated cancer?

Answer 7

cholangiocarcinoma

Question 8

schistosoma haematobium

associated cancer?

Answer 8

bladder cancer (squamous cell)

Question 9

what percentage of cancers are associated with viruses? virus sufficient for cancer?

Answer 9

15%

necessary but not sufficient (correlative relationship, not causative)

not all tumors (Brukett’s) have a viral component

Question 10

human herpesviruses - what group causes cancer? what viruses specifically?

Answer 10

Gamma

EBV
HHV-8/KSHV

Question 10

human herpesviruses - what group causes cancer? what viruses specifically?

Answer 10

Gamma

EBV
HHV-8/KSHV

Question 11

EBV - what does it infect? how does it cause cancer?

Answer 11

oral epithelium –> b cells; virus mimics BCR and CD40 signals via LMP which activates b cells and leads to cell differentiation and growth

Question 11

EBV - what does it infect? how does it cause cancer?

Answer 11

oral epithelium –> b cells; virus mimics BCR and CD40 signals via LMP which activates b cells and leads to cell differentiation and growth

Question 12

HBV, HCV treatments

Answer 12

Interferon-a : HBV, HCV – blocks protein synthesis

ribavirin: HCV, blocks nucleic acid synthesis via guanine nucleotide synthesis

Question 12

Burkitt lymphoma - virus association? mutation? presentation?

Answer 12

EBV

8:14, MYC and Ig translocation in B-cells, starry sky pattern in histo, think HIV

jaw lesion in dendmic form in africa
pelvis or abdomen in sporadic

Question 13

Kaposi sarcoma - virus? presentation?

Answer 13

HHV-8

endothelial neoplasm in HIV/transplants

dark flat lesions on skin

Question 14

HBV, HCV treatments

Answer 14

Interferon-a : HBV, HCV – blocks protein synthesis

ribavirin: HCV, blocks nucleic acid synthesis via guanine nucleotide synthesis

Question 15

ribavirin - mechanism? clinical use? toxciity?

Answer 15

mechanism: –I synthesis of guanine nucleotides by –I inosine monophosphate dehydrogenase
use: RSV, HCV chronic infection
toxicity: hemolytic anemia, severe teratogen

Question 19

JC virus
virus type? genetic material?
disease?

Answer 19

polyomavirus, DNA

progressive multifocal leukoencephalopathy (PML) in HIV –> death; virus is reactivated when get immunocompromised

“JC=Junky Cerebrum”
“Don’t you Need A little JC” (DNA virus)