26-Motor7-BasalGanglia Flashcards
Main components of basal ganglia (x4)
- neostriatum (caudate and putamen)
- globus pallidus
- subthalamic nucleus
- substantia nigra
The ___ receives major inputs to basal ganglia
neostriatum
caudate and putamen grouped together because
they are cytoarchitecturally similar nuclei
neostriatum:
primary output neurons
spiny neurons
neostriatum:
two subtypes of spiny neurons
- GABA/substance P (SP)
- Gaba/enkaphilin (ENK)
SP
substance P
ENK
enkephalin
neostriatum:
secondary neurons
aspiny neurons and interneurons
corticostriate pathway originates from ___
many cortical areas, especially premotor and primary motor cortex
corticostriate pathway terminates on ___ neurons in ___
spiny (both subtypes), neostriatum
corticostriate neurons are [excitatory/inhibitory]
excitatory (glutamate)
corticostriate information reflects [specific/nonspecific] cortical activity
specific
thalamostriate originates from ___ thalamic nuclei
midline
thalamostriate neurons are [excitate/inhibitory]
excitatory (glutamate)
thalamostriate information reflects [specific/nonspecific] activity
nonspecific, from reticular formation (arousal and attention)
striatum outputs to ___ and ___
GPi and GPe
direct pathway involves GABA/___ neurons to ___
SP, GP_i
indirect pathway involves GABA/___ neurons to ___
ENK, GP_e
globus pallidus (internal) is major [input/processing/output] system
output
GP_i projects to ___
VA/VL of thalamus
GP_i is mainly [excitatory/inhibitory]
inhibitory (GABA)
GP_e projects to ___
subthalamic nuclei (STh)
STh
subthalamic nuclei
GP_e in mainly [excitatory/inhibitory]
inhibitory (GABA)