Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MOHD 4.2 > 25 - DNA Viruses Part 2 (Stapleton) > Flashcards

25 - DNA Viruses Part 2 (Stapleton) Flashcards

1
Q

HPV causes what

A

cell division-hyperplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

cytopathic effect of papilloma virus

A

koilocytosis-large swollen cells with distorted nuclei

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

HPV proteins causing cancer

A

E6-inhibit p53

E7-inhibit retinoblastoma protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

high risk papilloma virus

A

causes cancer
highly active E6 and E7
cervical, anal, oropharyngeal cancer
leading killer of 20-29 year olds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

low risk papilloma virus

A

benign, warts
poorly active E6 and E7
cutaneous, genital warts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

papilloma virus transmission

A

personal contact
sexual
enter site of trauma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what serotype for high risk hpv

A

16 and 18

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

hpv treatment/prevention

A

no antiviral treatment

virus like particle vaccine for ages 9-26

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

polyomavirus characteristics

A

small, naked, circular dsDNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

types of polyomavirus

A

JC virus

BK virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

polyomavirus spread

A

respiratory transmission

latent in kidneys, CNS, bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

BK virus causes

A

urinary tract disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

JC virus casuses

A

progressive multifocal leukoencephalopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

adenovirus characteristics

A

naked
icosahedral
linear dsDNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

life cycle of adenovirus

A

fiber protein interacts with CAR receptor
nuclear replication
replicates vDNA using own DDDP
egress by cell destruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

infection from adenovirus

A

infection of mucosal epithelial cells

site depends on virus type and fiber protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

adenovirus spread

A

fecal oral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

adenovirus symptoms

A 
URI
keratoconjuntivits
pharyngitis
pharyngoconjunctivitgs
laryngitis
tracheobronchitis
bronchiolitis
infantile diarrhea
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

adenovirus treatment

A

no antiviral
no vaccines
handwashing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

parvovirus characteristics

A 
smallest DNA virus
naked
icosahedral
ssDNA
replicate in nucleus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what is the receptor for parvovirus

A

RBC P antigen

infects RBC precursors

22
Q

clinically significant parvovirus

A

B19

23
Q

primary and secondary infection of parvovirus

A

cytopathic, kills reticulocytes

non infectious, rash, arthritis

24
Q

parvovirus symptoms

A

fifths disease-slapped cheek rash
arthritis in adults
aplastic anemia (sickle cell crisis)
congenital infection (hydrops fetalis, fetal loss, fetal anemia)

25
Q

parvovirus treatment

A

no antiviral or vaccine

26
Q

hep b antigens

A

envelope protein/surface antigen - HBsAg
core antigen HBcAg
e antigen HBeAg (released)

27
Q

function of core antigen

A

carries polymerase with virus RDDP

28
Q

hep b life cycle

A 
HBsAg binds receptor
capsid migrates through NPC
release DNA into nucleus
gene expression in nucleus
mRNA transported to cytoplasm
egress into membrane with HBsAg
29
Q

gRNA

A

used as pregenome packaged in virion with RDDP- makes DNA copy of gRNA

30
Q

acute hep b

A

more likely to clear
more severe with age
IgM anti HBc and HBsAg

31
Q

chronic hep b

A

common with infected babies
cirrhosis, end stage liver disease, hepatocellular carcinoma
No HBsAb

32
Q

antibody to HBsAg

A

is protective!!!

induced by vaccine

33
Q

hep b treatment

A 
interferon a, nucleoside reverse transcriptase inhibitors
HBsAg vaccine (will have anti HBs antibodies)
34
Q

hep d

A

defective, requires HBV

enveloped, negative circular RNA

35
Q

disease from hep d

A

cannot occur without hep b

treat or prevent hep b

36
Q

hep b and d coinfection

A

acquired together

fulminant hepatitis

37
Q

hep b and d superinfection

A

hdv superimposed on chronic hbv

chronic hepatitis and cirrhosis

38
Q

hep with fecal oral

A

a and e

39
Q

hep with blood

A

b, d, c

40
Q

a virus family

A

picornavirus

41
Q

b virus family

A

hepadna

42
Q

c virus family

A

flavivirus

43
Q

d virus family

A

subviral

44
Q

e virus family

A

calici

45
Q

acute jaundice

A

all but c

46
Q

chronic hepatitis

A

all but a and e

47
Q

liver cancer risk

A

b and c

48
Q

TSE characteristics

A 
slowly progressive
lethal
no treatment
infrctious
difficult to destroy
49
Q

how are TSE created

A

misfolded PrP (PrPsc=prion)
misfold and aggregate
kill neurons and lead to disease

50
Q

noninfectious TSE

A

Familial CJD

sporadic CJD

51
Q

infectious TSE

A

kuru (cannibalism)
iatrogenic (growth hormone, grafts, infected instruments)
BSE-mad cow disease

MOHD 4.2 (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions