Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MOHD 4.2 > 24 - DNA Viruses Part 1 (Stapleton) > Flashcards

24 - DNA Viruses Part 1 (Stapleton) Flashcards

1
Q

naked DNA viruses

A

papilloma
parvoviridae
adenoviridae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

enveloped DNA viruses

A

herpesvirus
hepadnavirus
poxviridae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

herpesvirus characteristics

A 
large dsDNA
icosahedral
enveloped
establish lifelong latency in host
severe disease in immunocompromised
8 types
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

entry of herpesvirus

A

receptor mediated fusion of envelope with plasma membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

transcription of herpes virus

A

Intermediate early-start transcription
early genes-replication
late genes-structural genes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

lytic life cycle DNA synthesis

A

nucleoside kinase phosphorylates nucleoside needed for DNA transcription
DNA polymerase transcribes new viral DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

herpes replicates episomally

A

independent of host chromosome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

herpes egress

A

assembly in nucleus
traverse nuclear membrane
enter golgi body and traffic to plasma membrane to leave cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

herpes latency

A

viral lytic gene is turned off
latent gene is turned on-highly restricted, only a few genes
latent and lytic viruses are different population of cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

herpes pathogenesis

A

transmission contact with secretions
lytic replication in cells
virus passed to population for latency and maintained in these cells for remainder of hosts life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

HSV-1

A

common worldwide
spread by close contact
asymptomatic and symptomatic sheddin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

HSV-1 infection

A

initially at epithelial cells at mucocutaneous surfaces
spread to sensory nerves
ascend axons to nearest ganglion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

cold sore latency where

A

trigeminal gangion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

HSV-1 reinfection

A

traffic down sensory neuron to infect epithelial cells at original infection
lytic infection
epidermal destruction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

HSV-1 symptoms of primary infection

A 
asymptomatic
primary gingivostomatits
ocular herpes
herpetic whitlow
genital herpes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

HSV-1 pathology

A

diagnostic
multinucleated giant cells
inclusion bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

HSV-1 symptoms of reinfection

A 
asymptomatic
cold sore
herpes keratitis
herpetic whitlow
herpes encephalitis
genital lesion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

HSV-1 in immune deficiency

A

severe and long lived disease
visceral disease
encephalitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

HSV-2 characteristics

A

worldwide
less prevalent than HSV-1
spread sexually

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

HSV-2 latency

A

in spinal gangion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

HSV-2 primary infection

A

asymptomatic
genital herpes
neonatal herpes
primary gingivostomatits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

HSV-2 reinfection

A

asymptomatic
genital herpes
cold sores

23
Q

varicella zoster virus characteristics

A

worldwide
respiratory spread
no asymptomatic sheddin

24
Q

chicken pox symptoms

A

fever
malaise
pruritic vesicular rash

25
Q

chicken pox pathogenesis

A

respiratory infection
traffic from lungs to organs to skin
virus released by sneezing or coughing

26
Q

chicken pox latency

A

ascend up sensory axons to sensory ganglia

27
Q

reactivation of chicken pox

A

herpes zoster/shingles
rash on single dermatome
post herpetic neuralgia

28
Q

chickenpox vaccine

A

live attenuated virus

2 doses

29
Q

shingles vaccine

A

adults >60 years

30
Q

EBV characteristics

A

worldwide

spread by close contact (kissing disease)

31
Q

EBV pathogenesis

A

replication in oropharyngeal cells
spread to circulating B cells-swollen lymph nodes and spleen
viremia from replication in circulating B cells

32
Q

EBV reactivation

A

viral spread to epithelial cells in oropharynx

oropharyngeal and B cells shed EBV in saliva

33
Q

EBV primary infection

A

mononucleosis

34
Q

mononucleosis symptoms

A

fever, pharyngitis, lymphadenopathy, splenomegaly,

atypical lymphocytosis

35
Q

EBV reactivation

A

asymptomatic shedding

36
Q

acute EBV tests for diagnosis

A

monospot positive
heterophile antibody positive (production of IgM)
EBNA negative

37
Q

EBV tumors

A

B cell lymphoma
burkitts lymphona
nasopharyngeal carcinoma

38
Q

prior EBV diagnosis

A

EBNA positive

39
Q

CMV characteristics

A

worldwide

close contact/sex spread

40
Q

CMV pathogenesis

A

primary infection of mucosa
latency in monocytes
reactivation and shedding

41
Q

shedding of CMV blocked by

A

CD8 T cells

42
Q

CMV symptoms

A

atypical lymphocytes
fever, pharyngitis
adenopathy
NO heterophile antibody

43
Q

congenital disease of CMV

A

birth defects

deafness, vision impairment, developmental abnormalities

44
Q

HHV-6 characteristics

A

in 90% of adults
acquire in childhood
spread by close contact

45
Q

HHV-6 pathogenesis

A

spread by saliva
latent in T cell, monocytes, macrophages
reactivation is asymptomatic

46
Q

HHV-6 symptoms

A

roseola- rash

fever

47
Q

HHV-7

A

rarely cause disease

can cause roseola

48
Q

HHV-8 characteristics

A

causes kaposi sarcoma
sexual transmission
seen in mediterranean men and men with AIDS

49
Q

HHV-8 pathogenesis

A

infects B cells and endothelium
latency in B cells
shedding in saliva and semen
In immune suppressed

50
Q

HHV-8 treatment

A

no vaccine

treat underlying immune deficiency

51
Q

pox virus characteristics

A

largest human virus
enveloped
linear DNA

52
Q

poxvirus types

A

orthopox
parapox
yatapox
molluscipox

53
Q

orthopox causes

A

smallpox

54
Q

molluscum contagiosum

A

spread by contact or fomite
painless skin nodules with virus inside
STI

MOHD 4.2 (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions