23 Flashcards

1
Q

can we make vitamins

A

no

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2
Q

how do we acquire free radicals? (ROS and RNS=

A

endogenously by body

exogenous by pollution

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3
Q

how do free radicals work

A

they steal electron from a molecule (oxygen or nitrogen) which will then steal an electron from another maybe important molecule thereby changing its structure!!!! BAD

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4
Q

what produces reitnoic acid

A

vitamin A

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5
Q

what effect does retinoid acid have

A

effect on DC . allow them to change the receptors on T cells so they can bind gut endothelium

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6
Q

where is b12 found

A

meat and dairy food

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7
Q

where is vitamin d found

A

sun oily fish orange juicy

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8
Q

what vitamin needs to be monitored in vegans

A

d

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9
Q

which types of vitamins can be stored

A

fat soluble in liver.

and small amount of b12 in liver too

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10
Q

which types of vitamins often act as coenzymes

A

water soluble

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11
Q

which types of vitamins is excreted when in excess

A

water soluble

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12
Q

which types of vitamins is toxic in excess

A

fat soluble

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13
Q

where do fat soluble vitamins go

A

micelles then chylomicrons then lymph fluid

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14
Q

where do water soluble vitamins go

A

portal vein

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15
Q

what two vitamins are provided by and consumed by bacteria

A

BaKteria

BK

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16
Q

what are some causes of vitamin deficiency in developed countries

A

decreased intake (b)
vegans
elderly
no sun

or 
decreased absorption
malabsorption (coeliac disease) folate and b9
ill disease b12
liver and biliary tract: fatsol vitamins
intestinal bacterial overgrowth b12
oral antibiotics vitK
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17
Q

what are old ppl more likely to suffer from in terms of vitamin deficiency

A

folate

D

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18
Q

what are anorexic ppl more likely to suffer from in terms of vitamin deficiency

A

folate

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19
Q

what are alcoholic ppl more likely to suffer from in terms of vitamin deficiency

A

B1

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20
Q

vitamin a deficiency clinical features

A

xerophthalmia (eye dryness)

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21
Q

vitamin d deficiency clinical features

A

osteomalacia and rikkets

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22
Q

vitamin e deficiency clinical features

A

peripheral neuropathy

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23
Q

vitamin k deficiency clinical features

A

coagulopathies

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24
Q

vitamin c deficiency clinical features

A

scurvy

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25
vitamin b1 deficiency clinical features
beriberi
26
vitamin b2 deficiency clinical features
magenta tongue
27
vitamin b3 deficiency clinical features
pellagra
28
vitamin b6 deficiency clinical features
aniema
29
vitamin b12 deficiency clinical features
amemia
30
folate deficiency clinical features
anemia
31
what micronutrients are associated with anaemia
b6 b12 folate
32
what are trace elements
important dietary minerals
33
give me example of trace elements
``` calcium phosphorus iron selenium zinc copper ```
34
what does selenium deficiency lead to
cardiomyopathy
35
what does phosphorus deficiency lead to
bone pain | fracture
36
whats the function of team cheaters
prevent iron overload
37
how and where is iron stored
as ferritin in liver
38
whats transferrin
plasma glycoprotein that binds iron in blood
39
deficiency in iron
microcytic anemia
40
excess iron
hemochromatosis fatigue abd pain
41
how much sunlight do caucasians need
20 30 mintues | 2000 iU
42
how much sunlight do noncaucasians need
2-10 times more than cuacaisnas
43
what rickets
occurs before epiphyseal fusion | causes growth retardation and expansion of the growth plate.
44
what osteomalacia
reduced bon strength increase fracture
45
whats calcitrol
vitamin d
46
whats another name for b1
thiamine
47
where is b1 absorbed
jejunum
48
why is b1 impt
thiamine pyrophsohphate is involved in krebs cycle pentose phospate pathway
49
wet beri beri
enlarged heart tachycardia peripheral neuritis HF
50
dry beri beri
symmetric peripheral neuropathy muscle pb
51
shoshin beri beri
cardiac failure | lactic acidosis
52
Wernicke’s / Korsakoff’s symdrome​
cause: b1 def Wernicke’s encephalopathy​ Horizontal nystagmus (involuntary, rapid and repetitive movement of the eyes)​ Ophthalmoplegia (paralysis or weakness of the eye)​ Cerebellar ataxia (inflamed cerebellum)​ ACUTE ​ CHRONIC Korsakoff syndrome​ Mental impairment (additional loss of memory and a confabulatory psychosis)​ =The chronic neurologic sequels of Wernicke’s encephalopathy. It is irreversible!
53
B3 other name and aborbed where
niacin generic name for Nicotinic acid and nicotinamide | jejune
54
why is b3 impt
niacin form NAD and NADP for Krebs cycle
55
where can cells get niacin other than from diet
from tryptophan
56
what causes b3 def
vegan hartnups disease carcinoid synfrom isoniazid use
57
b3 deficiency disease
pellagra early: loss of appetite weakness and pain ``` later: DDDD diarrohea dementia dermatitis death ```
58
lack of folate
neural tube defect
59
vit12 deficiency pb
CVD
60
b12 importance
Cofactor for methionine synthase and methylmalonyl–coenzyme A (CoA) synthase