22. Síndrome Anti-fosfolípido Flashcards
What is antiphospholipid syndrome (APS)?
An autoimmune disease associated with increased risk of thrombosis due to the presence of procoagulatory antibodies.
What are some typical clinical manifestations of APS?
- Recurring venous, arterial, and/or microcirculation thrombotic events (deep vein thrombosis, stroke, transient ischemic attack)
- Obstetrical complications (recurrent miscarriages, premature births).
Does APS manifest in isolation or alongside other diseases?
Both: in isolation or alongside other autoimmune diseases such as systemic lupus erythematosus (SLE).
In which patients should be suspect APS?
Patients with a history of thrombosis or miscarriage;
How is the diagnosis of APS confirmed?
By the detection of serum antiphospholipid antibodies (e.g., lupus anticoagulant, anticardiolipin antibodies).
What are antiphospholipid antibodies (aPL antibodies; aPAs)
A group of antibodies;
- Lupus anticoagulant
- Anti-cardiolipin
- Anti-β2-glycoprotein
That bind to plasma proteins with an affinity for phospholipid surfaces. Their presence may be associated with an increased risk of arterial and venous thrombosis, although they are also seen in asymptomatic patients.
What is the long-term management of APS?
Systemic anticoagulation with warfarin or heparin
What is Catastrophic antiphospholipid syndrome (CAPS)?
A rare but severe form of APS that requires immediate treatment.
T/F:
