2.1.1

Question 1

GROWTH FACTORS FOR ERYTHROPOIESIS (3)

Answer 1

erythropoietin
interleukin-3
stem cell factor
colony stimulating factor-granulocytes-macrophage

Question 2

RBC starts first as _______ before becoming ______ before its first stage which is pronormoblast

____ days from progenitor to release of reticulocyte
_____ days from pronormoblast to reticulocyte

Answer 2

Burst Forming Unit-Erythroid
Colony Forming Unit-Erythroid

18-21 days
3-5 days

Question 3

STAGES OF ERYTHRIPOIESIS

_______: first recognizable stage

1. aka
2. N/C ratio
3. remains in this stage for at least

Answer 3

Pronormoblast

1. Rubriblast
2. 8:1
3. 24hrs

Question 4

STAGES OF ERYTHRIPOIESIS

_______: dark staining of nucleus because of heterochromatin

1. aka
2. N/C ratio
3. remains in this stage for at least
4. Detectable ____

Answer 4

Basophilic Normoblast

1. Prorubricyte
2. 6:1
3. 24hrs
4. Hemoglobin

Question 5

STAGES OF ERYTHRIPOIESIS

_______: stage where it shows many shades of color

1. aka
2. N/C ratio
3. remains in this stage for at least
4. has so called ____ cytoplasm
5. This still has RNA but also has hemoglobin, this bluish grey coloration is called ______
   - affinity to many colors
6. used to describe stage that emphasizes an evidence of more hemoglobin synthesis as observed in color of cytoplasm

Answer 5

Polychromatophilic Normoblast

1. Rubricyte
2. 4:1
3. 30hrs
4. murky
5. Polychromasia
   - chromotophilia
6. Dawn of Hemoglobinia

Question 6

STAGES OF ERYTHRIPOIESIS

_______: last nucleated stage and incapable of mitosis

1. aka
2. N/C ratio
3. its nucleus is called ____
4. nuclear dissolution
5. hrs in this stage
6. in order for nucleus to be extruded, this amount of protein must be decrease
7. cell part that contains the nucleus that was pinched off

Answer 6

Orthochromic Normoblast

1. Metarubricyte
2. 1:2
3. Pyknotic
4. Pyknosis
5. 48hrs
6. Vimentin
7. Pyrenocyte

Question 7

STAGES OF ERYTHRIPOIESIS

_______: first non-nucleated stage

1. aka
   2.days in here before it leaves BM
2. upon leaving BM, this will enter what organ
3. at times, nucleus are not totally removed, what do you call the nuclear remnants in rbcs
4. reticulocyte was taken unless from the appearance of cell when stained in ____ as the cell is seen with granules following a pattern called ______

Answer 7

Polychromatophilic Normocyte

Reticulocyte
2. 1-2 days
3. Spleen
4. Howell-Jolly bodies
5. supravital stain; reticulum network

Question 8

STAGES OF ERYTHRIPOIESIS

_______: absence of nucleus, organelles, mitochondria, and rna

1. Side view shale
2. If front view, it has central pale area called ____
3. diameter
4. thickness
5. lifespan
   - after 120th day, dead cell will be removed by spleen this process is called

Answer 8

STAGES OF ERYTHRIPOIESIS

Mature Erythocyte

1. Biconcave disk
2. Central pallor
3. 7-8um
4. 1.9-2.5um
5. 120 days
   - splenic culling

Question 9

STAGES OF ERYTHROPOIESIS AND THEIR AKA

Answer 9

1. Pronormoblast (Rubriblast)
2. Basophilic Normoblast (Prorubricyte)
3. Polychromatophilic Normoblast (Rubricyte)
4. Orthochromic Normoblast (Metarubricyte)
5. Polychromatophilic Normocyte (Reticulocyte)
6. Mature Erythrocyte