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Question 1

FIRST LINE

1. cells that will give rise to the more mature stages (specific cell line)
2. they are ____ as they are ____ to become one specific cell line or linkage
   - CFU-G is committed to become ______
3. they are ________ as they can’t be describe morphologically, the only way to describe the, is thru ______

Answer 1

1. PROGENITOR CELLS
2. COMMITTED
   - GRANULOCYTES
3. MORPHOLOGICALLY UNIDENTIFIABLE; CELL MARKERS

Question 2

common myeloid progenitor
1.
2.
3.
—
common lymphoid progenitor
1.
2.
3.
4.

Answer 2

common myeloid progenitor
1. granulocyte-monocyte progenitor
2. eosinophil-basophil progenitor
3. megakaryocyte-erythrocyte progenitor
—
common lymphoid progenitor
1. dendritic cell
2. pre-b
3. pre-T
4. natural killer cell

Question 3

second line

1. these are ____ cells (if we discuss cell stages we start in these cells as they have specific description per stage)
2. they are _______ that are confined in ______
3. but, there are some immature stages that can also be found in circulation like:
   - ____ until ___% only
   - ____ until ___% only

Answer 3

1. precursor cells
2. morphologically identifiable
3. but, there are some immature stages that can also be found in circulation like:
   - band cells = 5%
   - reticulocyte = 2%

Question 4

granulocytes-monocytes progenitor starting precursor cells
1.
2.

eosinophil-basophils progenitor starting precursor cells
1.
2.

megakaryocytes-erythrocytes progenitor starting precursor cells
1.
2.

Answer 4

granulocytes-monocytes progenitor starting precursor cells
1. myeloblast
2. monoblast

eosinophil-basophils progenitor starting precursor cells
1. myeloblast
2. myeloblast

megakaryocytes-erythrocytes progenitor starting precursor cells
1. pronormoblast
2. megakaryoblast

Question 5

pre-b starting precursor cells
1.

pre-t starting precursor cells
1.

Answer 5

pre-b starting precursor cells
1. B lymphoblast

pre-t starting precursor cells
1. t lymphoblast

Question 6

equivalent in tissue cells
1. monocytes =
2. b lymphocyte =

Answer 6

1. macrophage
2. plasma cell

Question 7

______: proteins that regulate the production of blood cells

1. these include ___ & ____
2. they can ____ & ____ production
   - if cells are in excess, they can promote _____ so precursor won’t grow anymore
3. can be in the form of ___ & _____
4. they are _____ that regulate the production and destruction of blood
5. some are in the forms of (3)

Answer 7

GROWTH FACTORS

1. cytokines and hormones
2. inhibit and promote production
   - APOPTOSIS
3. PROTEINS OR GLYCOPROTEINS
4. REGULATORY FACTORS
5. HORMONES, INTERLEUKINS, COLONY STIMULATING FACTOR

Question 8

________: GROWTH FACTOR that is multipotent which means it is capable of regulating the growth of more than one cell line together with ______

1. CSF-Gum are different from CFU since they are ____ that gives rise to developing cells; while CSF ____ so it is growth factor

Answer 8

Interleukin-3 (IL-3); CSF-GM

1. PRECURSOR/ STEM CELL; STIMULATES

Question 9

1. GROWTH FACTOR for erythropoiesis
   - produced by _____
2. GROWTH FACTOR for thrombopoiesis
   - produced by _____
3. they both promote ____ & ____ production

Answer 9

1. Erythropoietin
   - KIDNEY
2. Thrombopoietin
   - LIVER
3. THROMBOCYTE & MEGAKARYOCYTE

Question 10

more about EPO
1. the stimulus in the kidney is ______ (lack of oxygen)
2. this stimulus will be detected by _____ of kidneys
3. kidneys will produce more EPO if sense this stimulus and its specific fin are:
- Increase _____ of precursor rbcs
- accelerates rate of ____ & ____
- inhibit _____ (this is when cells are too much, this will show up

Answer 10

1. HYPOXIA
2. PERITUBULAR CELLS
   3.
   - MITOSIS
   - PROLIFERATION AND MATURATION
   - APOPTOSIS

Question 11

more ligands:

1. Stimulates myeloid, erythroid and lymphoid progenitors
   - they are _______ or ______
2. primitive progenitor cells
   - tyrosine like ligand as it acts on the receptor of _______ (receives signals from outside and interpret signals to promote growth or primitive progenitor cell)
   - ______ disease caused by mutation in tyrosine kinase gene

Answer 11

1. Kit Ligand (KL)
   - STEM CELL FACTOR/ STEEL FACTOR
2. Fit-3 Ligand (FL)
   - TYROSINE KINASE
   - LEUKEMIA

Question 12

______: cell surface proteins that used in the recognition of lineage/differentiation

1. Release of RBCs is promoted by _____, _____, cells stage of maturation (_____), pressure exerted by the ______ frowth of cells
2. wbcs leave b, through ____
3. platelets are released to circulation thru

Answer 12

ANTIGEN MARKERS

1. erythropoietin, hypoxia, reticulocyte; intramarrow
2. chemotaxis
3. platelet shedding

Question 13

Antigen markers:
1. CD34
2. CD33
3. CD31
4. CD11c, CD114
5. CD71
6. CD2,CD3
7. CD4
8. CD8
9. CD10, CD19, CD20
10. CD16, CD56

Answer 13

1. Stem cell marker
2. Pan myeloid
3. Pan myeloid
4. Monocytes
5. Erythroid
6. Lymphoid, pan T cells
7. Helper/ inducer T cells
8. Suppressor/ cytotoxic T cells
9. Lymphoid, pan B cells
10. NK cells

Question 14

_______: identifiers of the cell

1. they can be in the form of ____ or ______
2. called ____ because their
   presence is unique in that cells
3. rules of markers are very important in ________
4. Marker behaves like an ____ that will react to corresponding antibody
5. They are called CD =
6. All progenitor cells ____+

Answer 14

MARKER

1. SURFACE MARKERS/ INTERNAL PROTEIN
2. MARKERS
3. Immunophenotyping
4. ANTIGEN
5. CLUSTER OF DIFFERENTIATION
6. CD34