2.1

Question 1

CHANGES DURING NORMAL BLOOD CELL MATURATION :

Cytoplasm:
1. Basophilia:
2. Size:

Nucleus:
1. Size:
2. Nuclear chromatin
3. Number or nucleoli
4. Staining from ____ to ____

Answer 1

Cytoplasm:
1. decreases
2. increases

Nucleus:
1. decreases
2. more course and clumped
3. decreases
4. reddish to bluish-purple

Question 2

CYTOPLASMIC CHANGES

1. more immature cell = more ____
2. cytoplasm is rich in ___
3. as it matures the amount of RNA _____, as it is ____ metabolically active
4. Exception ____ since it remains to be deep basophilic cytoplasm even on maturation
5. Another exception _____

Answer 2

1. basophilic
2. RNA
3. decreases; less
4. Plasmacyte
5. RBCs

Question 3

CYTOPLASMIC CHANGES: Granulation

1. only applies to __^_
2. RBCs are ___
3. Aggranular WBc:
4. Granular WBC:

Answer 3

1. WBCs
2. Aggranular
3. Lymphocyte, Monocyte
4. Basophils, Eosinophils, Neutrophil

Question 4

NUCLEAR CHANGES:

Size
1. as nuclear size decreases; cytoplasm ____
2. Mature rbcs are ____
3. In Basophils, Eosinophils, Neutrophils changes that occur in the nucleus is _____

Nuclear Chromatin
1. immature cells = ____ (fine and delicate chromatin, homogenous)
2. mature cells = _____ (nuclear chromatin and more coarse and clumped)
3. empty unstained portions

Answer 4

Size
1. increases
2. non nucleated
3. segmentation

Nuclear Chromatin
1. Euchromatin
2. Heterochromatin
3. Parachromatin

Question 5

NUCLEAR CHANGES

number of nucleoli
1. As it matures =

Staining
1. immature = ____ basophilic
2. mature = ____ basophilic

Cell size
1. Exception: since no mitosis occur in this
- nuclear division is called
2. Another exception since it is larger than more mature cell which is myeloblast

Nuclear Cytoplasm Ratio
1. Immature
2. Maturation
3. Further maturation
4. As the cell matures, NC ratio ____
5. Decrease in NC ratio is parallel to _____

Answer 5

number of nucleoli
1. decreases

Staining
1. less basophilic
2. more basophilic

Cell size
1. Megakaryocytes
- endocytosis
2. Promyelocyte

Nuclear Cytoplasm Ratio
1. 8:1
2. 6:1
3. 4:1
4. decreases
5. nucleus

Question 6

RELEASE OF CELLS FROM BM TO CIRCULATION

RBCS
1. influenced by the growth factor
- widens ____
- decrease expression of ____
- cells that have these adhesive molecules

others:
2. level of maturation (_______)
- the only red cell that can pass through which is the first non nculeated stage
3. pressure exerted by ___ of cells

Answer 6

1. erythropoietin
   - width
   - adhesive receptors
   - stroma cells

others:
2. cell deformability
- reticulocyte
3. intramarrow growth

Question 7

RELEASE OF CELLS FROM BM TO CIRCULATION

WBCS
1. influenced by the growth factor
2. number of ______
3. directional motility
- squeezing of WBCs

Answer 7

WBCS
1. interleukins
2. Circulating WBCs
3. Chemotaxis
- diapedesis

Question 8

RELEASE OF CELLS FROM BM TO CIRCULATION

platelets
1. __________
- the protruded cytoplasm will undergo ____ or ____ to become individual fragments so it can reach the circulation

Answer 8

1. cytoplasmic shedding
   - fragmentation/ shedding