2025 ECG Quiz 8 Flashcards
Cardiac Pharmacology
Adrenergic Receptors
A1 and B1 = stimulating
A2 and B2 = inhibition and/or negative feedback receptors
Adrenergic Agonists: Phenylephrine
Neosynephrine
Reflex Brady due to baroceptor feedback
Common way to dilute = 10mg vial into 100 ml bag
10mg x 10 ml (how many times 10 goes into 100 ml)
*Technique to calculate
Adrenergic Agonists: Ephedrine
Ephedra
A1, B1, B2
Effects can vary depending on the peron
Adrenergic Agonists: Epinephrine
Adrenaline
Used to help with bleeding during surgery by surgeon
Know how to dilute down with bupivacaine
Adrenergic Agonist: Norepinphrine
Levophed
Typically through central line to limit extravasation and tissue necrosis
Phentolamine as treatment
8mg/250ml bag = 32 mcg/ml
Bolus Syringe Want
8mcg/ml when treating in OR
Adrenergic Agonists: Isoproterenol
Isuprel
NO ALPHA ACTIVITY
Mainly replaced by Dobutamine
Adrenergic Agonists: Vasopressin
Pitressin
Used if phenylephrine isn’t working, 2nd line
V1/V2 in the kidneys
Typically used when adrenergic bp meds not working when pts didn’t stop aldosterone blockers or ACEis
Adrenergic Antagonists: Phentolamine
Phenoxybenzamine - oral med taken preop
Phentolamine used when pheochromocytoma (rare tumor on adrenals, releases catecholamines irregularly)
Propranolol
Inderal
Adrenergic Antagonists: Beta Blockers - Metoprolol, Atenolol, Carvedilol
Beta blockers all end in “lol”
Esmolol = more commonly used due to short duration
Metoprolol = for longer tachy situations
Adrenergic Antagonists: Beta Blockers - Labetalol
Trandate
No reflex tachycardia
Used to decrease HR and BP
Antiarrhythmics (Class I and II)
Most commonly used lidocaine
Bier Blocks common = carpal tunnel
Decrease myocardial depolarization with the sodium channel block
Class II = Beta Blockers
Antiarrhythmics (Class III)
Antiarrhythmics (Class IV)
Know the extremes
Antiarrhythmics: Calcium Channel Blockers - Non dihydropyridines
Antiarrhythmics: Calcium Channel Blockers - Dihydropyridines
end in “pine”
Nifedipine - typically taken at home
Nicardipine - commonly used in OR and stroke patients????
Antiarrhythmics: Others
Stable narrow, SVT use vagal maneuvers not working
resets not the heart
Vasodilators: Hydralazine
Most commonly used in OR
Vasodilators: Nitrates
Can combine with Hg to cause methemoglobin, methylene blue treatment
Vasodilators: Nitroglycerin
Not always in the OR Pyxis, but generally around the OR suit pyxis
Sublingual spray in OB to help with uterine relaxation
2% paste
Vasodilators: Sodium Nitroprusside
Cyanide Toxicity potential
More potent than Nitroglycerin
Anti-hypertensives: ACEi
Commonly taken at home
end in “pril”
Typically act in the lungs where the ACE is present
The cough with it is not really an allergy, more so a side-effect
1st line phenylephrine not working to fix hypotension, 2nd line vasopressin use
Anti-hypertensives: ARBs
Less coughing than ACEi
Adrenergic Agonists: Dopamine
Changes what receptors acts on dependent on dosage
Adrenergic Agonists: Dobutamine
Adrenergic Agonists: Milrinone
Primacor