2- Transplant Immunology Flashcards by Evelyn Brito | Brainscape

Q

Hyper acute rejection has what HS and necrosis

A

Fibrinoid necrosis

Type II

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Q

What is the name if a graft from a twin

A

Syngenetic graft

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Q

Most important effector cell in graft destruction

A

Cd8+ T cells

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Q

Macrophages release of IL-1 does what

A

Proliferation of host CD4 T cells

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Q

What do cd4 T cells release

A

Lymphokines(B cells and ab) and

iL-2 (B cells , cd4 and cd8)

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Q

Macrophages il1 is blocked by what

A

Corticosteroids

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Q

Il2 from cd4 T cells is blocked by what

A

Cyclosporine a

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Q

Chronic rejection characterized by

A

Progressive organ dysfunction

And vessels fibrosis

Activated macrophages deposit collagen

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Q

GVHD diagnosis

A

Colon biopsy showing exploding crypt cells- nuclei fragments

Jaundice

Macularpapular

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Q

What can chronic rejection lead to

A

Organ failure

Bronchiolitis obliterans

Restrictive lung disease **

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