19-thyroditis Flashcards
Hashimoto’s thyroiditis histology ?
Lymphoid follicles composed of aggregated lymphoid cells with germinal centers and B cells
Background thyroid cells
Pale areas -fibrosis
Most common form of thyroiditis
Hashimotos
Hashimotos gene association is ?
HLA DR-5
The cells that stimulate antibody production in Hashimotos
Cd4t cells
The thyroid in hashimotos is destroyed by what cells ?
Cd8 T cells
Hasitoxicosis
Initial hyperthyroidism of Hashimotos
Initial thyrotoxicosis
What is the most common cause of painful thyroid gland ?
Subacute Granulomatous thyroiditis - de quervains thyroiditis
Histology of de quervains thyroiditis ?
Granulomatous inflammation with mutlinulcleated giant cells
macrophages
Subacute Granulomatous thyroiditis uptake scan ** unlike other hyperthyroidism
Reduced because inflammation involves destruction of thyroid follicles
What virus can cause de quervains disease?
Coxsakie a
What usually causes Acute thyroiditis ?
Staph aureus
The thyroid of acute thyroiditis presents with
Cervical lymphadenopathy
What is the most common form of thyroid enlargement in the United States
Sporadic goiter
Micro of multinodular goiter
Colloid rich irregular enlarged follicles lined by flat follicular cells
Gross anatomy of mutlinodular goiter
Irregular nodules with cyst formation and areas of hemorrhage and fibrosis
Ab in Hashimotos
Antithyroglobulin
Antimicrosomal-thyroperoxodase ab
Anti thyroid peroxidase
TSH receptor inhibitor
Hashimotos has an increased incidence for what cancer
Mantle cell lymphoma - from shrinkage suddenly enlarges . This is when it’s cancer
What is the analog of t4
L-tyroxine
Course of subacute granulomTous thyroiditis - de quervains thyroiditis
Euthyroid- transient hyperthyrodism - euthyroid
What is the consistency of the thyroid in reidels thyroiditis
Irregular hard woody consistency that adheres to surrounding structures of neck
Fibrosis
Who does reidels affects
People in their 30-40
Who gets subacute lymphocytic thyroiditis
3-6 month postpartum
In subacute Granulomatous thyroiditis painful or painless
Painful
Is subacute lymphocytic thyroiditis painful or painless
Painless
Goiter thyroid levels
Normal t3-t4
Increased TSH
What causes a simple colloid goiter to turn to a nodular goiter
Degenerative changes that evoke hemorrhage fibrosis and calcification
What is a dyshormogenic goiter
Goiter that develops due to deficiency of enzyme involved in synthesis of thyroid hormones
What are the characteristics of a multinodular goiter
Multilobed assymetrical enlarged follicles lined by flat follicular cells
A simple goiter is
Diffused nontoxic
Mutlinodular goiter can become
Plummers disease is what ?
Toxic nodular goiter called plummers disease
Which is when one or more nodules become TSH independent and lead to increase in t3 and t4 releasing be and causing thryotoxicosis- hot nodules
How are most people with mutlinodular goiters
Euthyroid
