1st gen Antipsychotics and EPS meds Flashcards
Chlorpromazine
50 to 2000
High sedation and hypotension
medium EPS and anticholinergic
Allergic dermatitis, photosensitivity, QTc changes
Mesoridazine
100 to 400mg
High anticholinergic, sedation, hypotension
Low EPS
QTc changes
Thioridazine
50 to 800mg
High anticholinergic, sedation, hypotension, prolonged QTc
Low EPS
Irreversible retinal pigmentation at doses above 800
Sexual dysfunction
Fluphenazine
2 to 40mg daily
12.5 to 75mg IM biweekly
Very high EPS
Perphenazine
8 to 64 mg
High EPS
Trifluoperazine
5 to 80mg
High EPS
Low anticholinergic, sedation, hypotension
Haldol
2 to 40mg daily
50 to 300mg monthly
Very high EPS
High anticholinergic and sedation
Low hypotension
In older adults, monitor for oculogyric crisis and pneumonia
Loxapine
20 to 250 mg daily
High EPS
Moderate sedation, hypotension
Low anticholinergic
Molindone
50 to 225mg
High EPS
Low anticholinergic
very low sedation
Little or now weight gain
Thiothixene
5 to 60
High EPS
Treatment of TD
the best treatment is prevention. If it occurs, lower the dose, switch to an atypical, or give that new drug.
Benztropine
0.5 to 2mg
Treats akinesia, aakathisia, dystonia, pseudoparkinsons
Procyclidine
2.5 to 5mg
Treats akinesia, aakathisia, dystonia, pseudoparkinsons
Trihexyphenidyl
2 to 5mg
Treats akinesia, akathisia, dystonia, pseudoparkinsons
Diphenhydramine
Treats akinesia, dystonia, pseudoparkinsons
