18. Intro to the Immune System Flashcards by idhil Unknown | Brainscape

Q

Myeloid progenitor cells give rise to…

A

red cells and phagocytes

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Lymphoid progenitor cells give rise to…

A

B and T lymphocytes

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Erythropoietin

A

production of erythrocytes

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Thrombopoietin

A

development of platelets

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

GM-CSF (Granulocyte Macrophage Colony Stimulating Factor)

A

development of leukocytes

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

RBC

A

formed by erythropoiesis in the bone marrow

no nucleus

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Platelets

A

form plugs

no nucleus

lifespan = 7-10 days

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

T cells

A

CD4+ = helper T cells

CD8+ = cytotoxic T cells

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

B cells

A

produce and secrete antibodies

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Dendritic Cells

A

APCs

3 main types:

Langerhans cells (skin)

Interdigitating cells (Lymph node)

Follicular Dendritic Cells (B cell follicle)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Monocyte

A

kidney-shaped nucleus

become macrophages in the tissues

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Macrophage in liver

A

kupffer cells

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Neutrophil

A

multilobed nucleus

early inflammatory response

granules contain proteases

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Eosinophil

A

kills parasites that cannot be digested

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Basophils and Mast cells

A

Both cells secrete histamine and heparin

Basophils circulate in blood, mast cells don’t

acute inflammatory response

important in allergy and hypersensitivity

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

NK Cells

A

kill by inducing lysis and apoptosis

Q

primary lymphoid organs

A

Thymus and Bone Marrow

Q

Secondary lymphoid organs

A

The Spleen

Skin

Q

What does the spleen do?

A

blood ‘filter’ = removes dead RBCs

Q

asplenia

A

Rare individuals are born without a spleen

Problems with generating antibodies

High susceptibility to bacteremia

Q

A

Schistosoma mansoni

increased portal pressure and enlargement of the spleen

spleen can rupture leading to death

Q

Mucosal Associated Lymphoid Tissue (MALT)

A

These tissues include:

The respiratory tract

The gastro-intestinal tract (Peyers patches)

The genito-urinary tract

Q

What % of lymphocytes are lodged in the spleen

A

25%

Q

Macrophage in brain

A

microglia

Q

Macrophage in kidney

A

mesangial cells

Q

Macrophage in bone

A

osteoclasts