17 - LARGE SCALE CHROMOSOMAL CHANGES Flashcards
what is Cri-du-chat syndrome
what are possible causes of chromosomal deletions
what is a possible explanation for the Williams syndrome deletion
what are ways to detect chromosomal deletions
- observing their length of pairing
- doing a complementation test
- DNA analysis using genomic techniques
what is the concept behind a complementation test
what do you cross when you do a complementation test
how does a complementation test reveal deletions
how are known deletions used to map a recessive mutant allele
this means that the allele for eyes is on gene e
what are ways in which duplications can occur in chromosomes
what are large duplications called
called segmental duplications
how can chromosomal inversions happen
what are two types of inversions
paracentric: on the same side of the centromere
pericentric: across a centromere
what are possible somatic consequences of chromosomal inversions
no genes disrupted
one gene disrupted
fusion of two genes
when does chromosome recombination occur
how does an inversion happen during meiosis
what does this paracentric inversion cause
what does a pericentric inversion cause
