17 Flashcards
liver biopsy for chronic hepatitis will show
inflammation- lymphs + plasmacytes
hepatocellular necrosis
fibrosis
no underlying cause
how to treat chronic hepatitis
- steroids- but caution in not symptomatic dogs
- cyclosporine
- metro
- ursodiol
copper in chronic hepatitis diagnosis
- biopsy looks like CH
- copper staining in centrilobular areas
treatment for copper hepatitis
low copper diet
copper chelation- D-penicillamine
cirrhosis will cause portal — which leads to —
- hypertension
- ascites and acquired portosystemic shunts from blood trying to find path of least resistance
- liver enzymes may be ↑ or normal, if liver not functioning enough to make them
treatment for cirrhosis
supportive care
can try antifibrotics: colchicine, steroids
how is acetaminophen toxic
tylenol
- metabolite NAPQI is toxic
- worse in cats
c
clinical signs of acetaminophen toxicity in dog
dog: centrilobular hepatic necrosis and occasional renal lesion
clinical signs of acetaminophen toxicity in cats
methemoglobinemia usually occurs prior to hepatic damage (necrosis can occur)
- tylenol- toxic dose much lower in cats
treatment for acetaminophen toxicity
tyelonol
* emesis and gastric lavage
* glutathione precursors: N-acetylcysteine (mucomyst), S-adenosylmethionione
* ranitidine- inhibit cp450
phenobarbital can cause — dermatitis
superficial necrolytic dermatitis
* crust, ulcers and erosions on footpads and muzzle
rimadyl can cause liver toxicity in
random- usually 3 weeks after starting
* hepatocellular necrosis
* usually get better if you stop it
— can cause liver toxicity in black and tan or white coated dogs
Trimethoprim sulfa drugs
* high dose, within 30 days of starting
most common liver tumor in dog
hepatocellular carcinoma
solitary > diffuse
older
liver failure rare, low BG
how to diagnose hepatocellular carcinoma
biopsy
* can be single mass- surgery can be cure
