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Farma 1P > 1.5a Anticonvulsivantes :v > Flashcards

1.5a Anticonvulsivantes :v Flashcards

1
Q

MDA felbamato

A

Inhibe respuesta NMDA, potencia GABA

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2
Q

MDA de gabapentina, pregabalina

A

Unión alfa1delta1 del canal de Ca.

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3
Q

Pregabalina usos

A

Dolor neuropático y por lesiones en médula espinal
Neurálgia del trigémico (de elección)
TAG
Migraña, dolor crónico, biporalidad
Sd de piernas inquietas

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4
Q

Pregablina EA:

A

Somnolencia, ataxia, fatiga

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5
Q

MDA lamotrigina

A

Bloquea canales de Na
Inhibe liberación de glutamato

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6
Q

Lamotrigina usos

A

Lennox
Bipolaridad en fase depresiva
Anticonvulsivo de elección en embarazadas
Convulsiones tónico clónicas generalizadas secundarias y parciales (focales)

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7
Q

EA lamotrigina

A

depresión, mareo, ataxia, visión borrosa, Steven Johnson

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8
Q

El mejor antiepiléptico y su MDA

A

Levetiracetam
Se une a SV2A

Brivaracetam es su análogo

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9
Q

MDA perampanel

A

antagonista receptor AMPA (lit dice en el nombre)

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10
Q

Antiepiléptico que se une a SV2A

A

Levetiracetam (brivaracetam)

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11
Q

MDA tiagabina

A

Inhibe recaptura GABA (GABA GAT1)

Como EA puede empeorar crisis de ausencia !!!

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12
Q

MDA topiramato

A

Bloquea canales NA
Aumenta frecuencia apertura canales Cl
Activa corrientes K, disminuye corriente de Na
Disminuye corrientes Ca tipo T
Estimula GABA A
Inactiva AMPA
Inhibe anhidrasa carbónica
Disminuye estradiol plasmático

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13
Q

MDA zonisamida

A

Bloquea canales Na
Bloquea canales Ca tipo T
Inhibe anhidrasa carbónica

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14
Q

Acetazolamida

A

Inhibe anhidrasa carbónica

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15
Q

MDA lacosamida

A

Bloque canales Na
Se une a colapsina 2

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16
Q

EA lacosamida

A

Prolonga PR

17
Q

MDA rufinamida

A

Bloquea canales Na

18
Q

MDA vigabatrina

A

Inhibe degradación GABA

19
Q

Vigabatrina usos

A

Sd West

20
Q

Sd West tx

A

Vigabatrina

21
Q

EA vigabatrina

A

Pérdida progresiva bilateral de la vista

22
Q

MDA ezogabina

A

Activa canales K

23
Q

EA ezogabina

A

Dificultad para orinar
Psicosis
Ideación suicida
Prolongación QT
Deficit de memoria
Decoloración azul y anormalidades retinianas

24
Q

MDA estiripentol

A

Inhibe GABA transportador

Farma 1P (14 decks)

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