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BIOCA bioquímica > 14. Via De Pentosa Fostato Y NADPH > Flashcards

14. Via De Pentosa Fostato Y NADPH Flashcards

1
Q

Fase oxidstiva de via de pentosa fosfato

A

C1 de glucosa 6-P se libera como CO2 pruduciendo 1 azucar+ 2 NADPH reducidos

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2
Q

Dador mas importante de NADPH

A

Via de pentosas fosfato

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3
Q

Via de pentosa fosfato por cada glucosa crea

A

1 Ribosa 5-P
1 CO2
2 NADPH

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4
Q

Glucosa 6-P a 6-fosfogluconalactona y NADPH se da por

A

Glucosa 6-fosfato deshidrogenasa(G6PD)

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5
Q

Inhibidor comoetitivo de G6PD

A

NADPH

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6
Q

Gen G6PD activado por

A

Insulina

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7
Q

6-fosfogluconolactona hidrolasa crea

A

6-fosfogluconolactona a 6-fosfogluconato

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8
Q

6-fosfogluconato deshidrogenasa

A

6-fosfogluconato a ribulosa 5-P,CO2 y NADPH

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9
Q

Reacciones que dan NADPH

A

G6PD

6-fosfoglucomato deshidrogenasa

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10
Q

Ribulosa 5- fosfato se puede interconvertir a

A

Ribosa 5-P
Fructosa 6-P
Gliceraldehido 3-P

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11
Q

Trascetolasa covierten ribulosa 5-P a

A

Gliceraldehido 3-P y fructosa 6-P

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12
Q

Trancetolasa requeriere para mover 2 carbonos

A

Tiamina pirofosfato(TTP)

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13
Q

Transaldolasa

A

mueve 3 carbonos

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14
Q

Enzimas que requieren TPP

A

PDH
α-ceToglutarato deshidrogenasa
α-cetoacido deshidrogenasa de CR
Trancetolasa

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15
Q

Sus electrones se usan para biosintesis reductora

A

NADPH

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16
Q

NADPH funciona como reductor para

A

AG
Colesterol
Hormonas esteroideas

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17
Q

Familia de especies reacitvas de oxigeno (ERO)

A

H2O2
O2-
OH•

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18
Q

Glutation reducido(G-SH)

A

Tripeptido tiolico detoxifica H2O2

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19
Q

Selenoproteina cataliza

A

Glutatiom peroxidasa para formar glutatiom oxidada(G-S-S-G)

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20
Q

Glutation reducido se genera por

A

Glutatiom reductasa usando NADPH

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21
Q

Catalasa

A

H2O2 a O2 y H2O

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22
Q

O2•- con suoeroxido dismutasa

A

H2O2

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23
Q

Glutation peroxidasa

A

H2O2 a H2O

24
Q

Antioxidantes

A

Ascorbato
Vitamina E
β-caroteno

25
Q

Cirocromo P450

A

Uriliza NADPH para dar reducciones

26
Q

CYP

A

Familias de monooxigenasas

27
Q

CYP en MMI

A

Hacen que compuestos sean mas solubles en agua

28
Q

CYP en REL

A

Detoxifica xenobioticos

29
Q

Ingestion de microorganismos porreceptores de leucocitos y macrofagos

A

Fagocitosis

30
Q

Fagolisosomas y lisosomicas

A

Utilizan pH independientes de O2

31
Q

Matan bacterias dependientes de O2

A

NADPH oxidasa y Mieloperoxidasas(MPO)

32
Q

Cosumo de O2 para dar O2-

A

Estallido respiratorio

33
Q

Contiene flavocitrocromo y peptidos que se traslocan en citoplasma

A

NADPH oxidasa

34
Q

Electrones de NADPH a O2 por FAD y hemo crean

A

O2-•

35
Q

Enfermedad granulomatosa cronica por

A

Deficiencia en NADPH oxidasa

36
Q

O2- se covierte en H2O2 por

A

Súperoxido dismutasa

37
Q

Dentro de Fagolisoma se produce

A

HOCl(acido hipocloroso)

38
Q

NO puede actuar con

A

O2 y O2-

39
Q

Sustratos para NO sintasa citosolica(NOS)

A

Arginina, O2 y NADPH

40
Q

Productos de NOS

A

NO y citrulina

41
Q

Coenzimas de NOS

A

FMN
FAD
Hemo
Tetrahidrobiopterina

42
Q

Enzimas dependientes de CaM

A

eNOS(endotelio)

nNOS(neural)

43
Q

Enzima independiente de Ca

A

iNOS

44
Q

Inductores de iNOS

A

Factor de necrosis tumoral-α(TNF-α)
Interferon-γ(IFN-γ)
endotoxinas bacterianas (LPS)

45
Q

NO activa

A

Guanilil ciclasa o guanilato ciclasa y da cGMP

46
Q

cGMP elevado

A

Cierra canales Ca2

47
Q

O2- + NO

A

OH• bactericida

48
Q

Deficiencia se G6PD

A

Hemolisis por no hacer NAdPH

49
Q

Si G6PD disminuye en eritocitos

A

No se reservara G-SH

50
Q

Si se oxidan G-SH crean

A

Cuerpos de heinz

51
Q

Deficiencia de G6PD sintomatica

A

Medicamentos oxidantes
Favusmo
Infeccion

52
Q

A AA significa

A

Antibioticos(sulfametoxazol y cloranfenicol)
Antipaludicos(primaquina)
Antipireticos(acetidina)

53
Q

G6PD A-

A

Forma moderada (III) 10%-60%

54
Q

G6PD mediterránea

A

Grave II

55
Q

Ausencia total de G6PD

A

Letal

BIOCA bioquímica (25 decks)

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