1.2ciii - Reversible Binding of Phosphate and the Control of Conformation Flashcards
The addition or removal of phosphate can cause…
reversible conformational changes in proteins
The addition or removal of phosphate is a common form of
post-translational modification
Protein kinases catalyse…
the transfer of a phosphate group to other proteins
The terminal phosphate of ATP is…
transferred to specific R groups
Protein phosphates catalyse the…
reverse reaction
Phosphorylation brings about…
conformational changes, which can affect a protein’s activity
The activity of many cellular proteins is regulated by…
phosphorylation
Cellular proteins that are regulated by phosphorylation include…
enzymes and receptors
Some proteins are activated by phosphorylation, while others are…
inhibited
Adding a phosphate group adds…
negative charge
Ionic interactions in the unphosphorylated protein can be…
disrupted and new ones created
