Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > 12.1 Drugs used in Psychiatric Disease > Flashcards

12.1 Drugs used in Psychiatric Disease Flashcards

1
Q

What are the core symptoms of depression?

A

Low mood
Anhedonia
Low energy
(2/3 needed)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are some secondary symptoms of depresion?

A 
Decreased appetite
Sleep disturbance
Hopelessness
Self harm/suicidal thoughts
Decreased libido
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the monoamine hypothesis of depression?

A

Depression is due to lack of noradrenaline and serotonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the receptor hypothesis of depression?

A

Abnormality in receptors for monoamine transmission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the 3 hypotheses for depression pathophysiology?

A

Monoamine
Receptor
Gene expression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are some anti depressant drugs?

A 
Imipramine
Lofepramine
Citalopram
Fluoxetine
Sertraline
Venlafaxine
Amitryptilline
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which antidepressants are SSRIs?

A

Fluoxetine
Citalopram
Sertraline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How do SSRIs work?

A

They inhibit the reuptake of serotonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are some ADRs of SSRIs?

A 
Anorexia
Nausea
Diarrhoea
Precipitation of mania
Prolonged QT
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which antidepressants are TCAs?

A

Amitriptilline
Imipramine
Lofepramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How do TCAs work?

A

Inhibits NA reuptake
Muscarinic blockade
Alpha 1 blockade

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are ADRs of TCAs?

A

CNS sedation
Autonomic block - decreased glandular secretions
Tachy cardia, postural hypotension, decreased contractility
Constipation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which antidepressants are SNRIs (Serotonin, Noradrenaline reuptake inhibits)?

A

Venlafaxane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are some ADRs of SNRIs?

A

(Same as SSRI) Anorexia, nausea, diarrhoea

+ sleep disturbance, hypertension, dry mouth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are some positive symptoms of schizophrenia?

A

Hallucinations
Dellusions
Thought disorders
Abnormal behaviour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are some negative symptoms of schizophrenia?

A

Blunted effect

Social withdrawal

17
Q

What are some cognitive symptoms of schizophrenia?

A

Selective attention
Poor memory
Reduced abstract thought

18
Q

What are some possible causes of schizophrenia?

A

Dopamine too high?
Serotonin too high?
Decreased glutamate function?

19
Q

What are some typical schizophrenia drugs?

A

Haloperidol

Chlorapromazine

20
Q

What are some atypical schizophrenia drugs?

A

Olanzapine
Risperidone
Quetiapine
Clozapine

21
Q

What are some side effects of typical antischizophrenia drugs?

A 
Extrapyramidal - Parkinsonism, tardive dyskinesia, acute dystonia
Neuroleptic malignant syndrome
Postural hypotension
Weight gain
CNS depression
Cardiotoxicity
22
Q

What are some side effects of atypical antischizoprenia drugs?

A

Weight gain
Hyperprolactinaemia
Extrapyramidal side effects if high dose

23
Q

What is anxiety?

A

Fear out of proportion to situation?

24
Q

What is used to manage anxiety?

A

CBT

Drugs - antidepressants, anxiolytics, sometimes antipsychotics

25
Q

What are some anxiolytics that can be used to anxiety treatment?

A

Diazepam

Lorazepam

26
Q

How do the benzodiazepine anxiolytics work?

A

Enhancing GABA and therefore inhibitory action on the brain

27
Q

What do you need to be careful about with benzodiazepines?

A

Don’t give too long a dose - tolderance and dependence can occur quickly

28
Q

What ADRs can occur with benzodiazepines?

A 
Drowsiness
Dizziness
Psychomotor impairment
Dry mouth
Decreased BP
29
Q

Benzodiazpines can be teratogenic, what problems can they cause in pregnancy?

A

Cleft lip and palate

Resp depression in late pregnancy

30
Q

What are some mood stabilisers in biploar disorder?

A

Lithium

Valproic acid

31
Q

What are some ADRs with lithium?

A 
Nephrotoxic
Memory problems
Thirst
Polyuria
Tremor
Hypothyroidism
32
Q

What can be used to treat dementia?

A

AChesterase inhibitors - donepezil, galantamine

NMDA antagonist - mamantine

33
Q

What are ADRs of ACh inibitors?

A

Nauesea, vomiting, anorexia, diarrhoea
Fatigue insomnia
Bradycardia
Peptic ulcers

34
Q

What are some ADRs of memantine?

A

Hypertension
Dyspnoea
Dizziness
Drowsiness

Pharmacology (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions