04.2 Cholesterol Flashcards

1
Q

What are some examples of statins?

A

Simvastatin

Atorvastatin

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2
Q

What is the mechanism of action of statins?

A

Inhibition of hepatic HMG-CoA reductase

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3
Q

What are some ADRs of statins?

A

Myopathy
Rhabdomyolysis
Increase plasma hepatic enzymes

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4
Q

What is an example of a fibrate?

A

Bezafibrate

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5
Q

What is the mechanism of action of fibrates?

A

PPAR alpha agonist

Increases lipoprotein lipase

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6
Q

What are some ADRs of fibrates?

A

Cholelithiasis
Myositis
Abnormal LFTs

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7
Q

How does nincotinic acid work?

A

Inhibits lipoprotein synthesis

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8
Q

What are some ADRs of nicotinic acid?

A
Flushing
Itching
Headache
Hyperglycaemia
Hepatotoxic
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9
Q

How does ezetimibe work?

A

Inhibits intestinal choelsterol absorption

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10
Q

What are some ADRs of ezetimibe?

A

Abdo pain
Diarrhoea
Headache

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