04.2 Cholesterol Flashcards
1
Q
What are some examples of statins?
A
Simvastatin
Atorvastatin
2
Q
What is the mechanism of action of statins?
A
Inhibition of hepatic HMG-CoA reductase
3
Q
What are some ADRs of statins?
A
Myopathy
Rhabdomyolysis
Increase plasma hepatic enzymes
4
Q
What is an example of a fibrate?
A
Bezafibrate
5
Q
What is the mechanism of action of fibrates?
A
PPAR alpha agonist
Increases lipoprotein lipase
6
Q
What are some ADRs of fibrates?
A
Cholelithiasis
Myositis
Abnormal LFTs
7
Q
How does nincotinic acid work?
A
Inhibits lipoprotein synthesis
8
Q
What are some ADRs of nicotinic acid?
A
Flushing Itching Headache Hyperglycaemia Hepatotoxic
9
Q
How does ezetimibe work?
A
Inhibits intestinal choelsterol absorption
10
Q
What are some ADRs of ezetimibe?
A
Abdo pain
Diarrhoea
Headache