1.2 Ab Reactions, intermolecular force and Zonal reactions Flashcards
These are foreign substances that contain binding sites
Antigens
This binding site for antigens is called antigenic determinant which is known as?
Epitope
Antigens can have more than one epitope
T or F
T
An antigen that has only one epitope (Incomplete antigens) that cannot stimulate immune response
Haptens
These are immunoglobulins that contains glycoprotein and binds to antigen
Antibody
These are antigens that can stimulate an immune response
Immunogens
All immunogens can be antigen but not all antigen is immunogens
T or F
T
Immunogens can posses epitope
T or F
T
Part of Antibody that can be seen in the terminal end of the Fab region that binds to antigen
Paratope
Combination of a Ag and its corresponding Ab is called?
Sensitization
Properties of immune complex is invisible and precise
T or F
T
Properties of immune complex where a concept of antibody binds to there corresponding antigen is called lock and key concept
T or F
T
Properties of immune complex is irreversible
T or F
F
Reversible
Properties of immune complex that the binding of this is covalent
T or F
F
Non covalent
Properties of immune complex is goverened by?
Law of mass Action
Intramolecular forces:
Occur between oppositely charged particles
Ionic or Electrostatic
Intramolecular forces:
Occur when Ag and Ab are in close proximity; attraction between polar molecules
Hydrogen bonds
Intramolecular forces:
Occur because of interaction between the electron clouds of oscillating dipoles
van der Waals
Intramolecular forces:
Occur between non-polar molecules
Hydrophobic bonds
Strength of the binding of the EPITOPE and ANTIBODY
Affinity
Overall binding strength between multivalent antibodies and Antigens
Avidity
What type of antibody associated mostly in Affinity?
IgG
What type of antibody is associated mostly with Avidity?
IgM
The higher the avidity the more likely the immune complex to be dissolve
T or F
F
Less likely
Forming lattice formation, their should a proportional amount of Ag and Ab
T or F
T
In Zonal Reactions:
Antibody excess
Prozone
In Zonal Reactions:
Antigen excess
Post zone
In Zonal Reactions:
Equal antibody and antigen
Zone of Equivalence
Prozone and postzone may not produce lattice formation
T or F
T
Remedy for prozone or postzone?
Dilution
Zone of Equivalence is the optimal Ag-Ab conc.
T or F
T
