12-2 2

Question 1

Alcoholic ketoacidosis rx

Answer 1

Dextrose
Ethanol cessation

Question 2

Wernicke/Korsakoff rx

Answer 2

Thiamine- 500 mg intravenous

Question 3

Methanol Metabolizes to formic acid, which can cause __________-

Answer 3

blindness

severe acidosis is a lab finding

Question 4

Methanol is associated with __________- and moonshine

Answer 4

windshield washer fluid

Question 5

________ is most common source of ethylene glycol

Answer 5

Antifreeze

Question 6

Ethylene glycol / Methanol rx

Answer 6

• Removal of contaminant w/ Hemodialysis
• Prevention of toxic metabolite formation w/ Fomepizole

pyridoxine - ethylene glycol
Folic acid - methanol

*get osm gap on labs

Question 7

Isopropanol vs other toxic alcohols

Answer 7

NO ACIDOSIS
Intoxication
Fruity odor due to ketones
Hemorrhagic gastritis

Management:
Supportive care
In severe cases, HD

Question 8

In APAP OD, The depletion of __________- causes liver damage

Answer 8

glutathione

Question 9

In APAP OD, Refer for liver transplant if

Answer 9

pH <7.3
Serum creatinine >3 mg/dL
INR >3
Grade III or IV encephalopathy by the West Haven Criteria

Question 10

In APAP OD, Continue NAC until

Answer 10

Toxicity resolves
Patient receives transplant
Patient dies

*NAC is safe in pregnancy

Question 11

NSAID OD is usually well tolerated but can consider __________- in severe metabolic acidosis

Answer 11

hemodialysis

Question 12

Naloxone Lowest possible dose = _____–

Answer 12

0.04 mg

*Methadone and fentanyl; may need up to 10 mg