11/16- 3.0 Flashcards
______________ may increase likelihood of HUS and are not recommended for patients with Shiga toxin-producing E. coli infection.
Antibiotics and antimotility agents
ITP is caused by?
caused by antibodies binding to platelet antigens, leading to their destruction
Most cases are self-limited.
ITP age range?
more common in children under 10 years old
Most cases are self-limited.
Outcomes are best if N-acetylcysteine is started within ______ time of APAP overdose
8 hours
If ingestion occurred more than 8 hours ago, an initial dose of N-acetylcysteine can be administered while awaiting acetaminophen concentration and comparison to Rumack Matthew nomogram to determine need for continuation.
APAP toxic dose
Single potentially toxic doses are >150 mg/kg or >10 g in adults.
The Rumack-Matthew nomogram cannot be used for?
staggered acute or chronic poisonings.
Treat with N-acetylcysteine if __________________ when the time of ingestion is unknown or chronic in nature.
-AST and ALT levels are elevated
-Any detectable APAP concentration
-Hx of APAP poisoning
Admit all patients receiving N-acetylcysteine
If the anticipated time from the first medical contact to PCI is___________ min, give TPA for STEMI if there is no contraindication
> 90-120
STEMI thrombolytic contraindications
- Any prior ICH
- structural cerebral vascular lesion
- malignant intracranial neoplasm (primary or metastatic)
- Ischemic stroke within 3 mo
- aortic dissection
- Active bleeding
- Significant closed-head or facial trauma within 3 mo
- Intracranial or intraspinal surgery within 2 mo
- Severe uncontrolled hypertension dewspite therapy
For streptokinase, prior treatment within the previous 6 mo
Tenecteplase (TNK-tPA) dose
70-79 kg: 40 mg
80-89 kg: 45 mg
>90 kg: 50 mg
STEMI tPA dose
>67 kg
Alteplase (tPA): 100 mg over 1.5 h
- 15 mg IV over 1-2 min –>
- 50 mg over 30 min –>
- 35 mg over the next 60 min
SAY this dose for defibrillation
200 J
then
300 J
then
360 J
