11.6.13 Molecular Biology Transcription part 6

Question 1

Required for general cell functions and cell viability.
enzymes of basic metabolism and proteins for cell structures such as ribosomes.
(house keeping genes/regulated genes)

Answer 1

house keeping genes

Question 2

cell-type specific genes which are responsible for the differentiated functions of specific cell types. These also include genes which respond to signals from other cells.
hormone/growth factor/stress responsive genes
(house keeping genes/regulated genes)

Answer 2

regulated genes

Question 3

(prokaryotic/eukaryotes) regulation involves Adjustment of metabolic requirement in response to nutritional environment

Answer 3

prokayrotic

Question 4

T/F e.coli prefers glucose above all other sugars

Answer 4

T

Question 5

cAMP is (high/low) when glucose is present

Answer 5

low

Question 6

DBP carry out (positive/negative) control with CAP-cAMP and (negative/postive) with lac and trp repressor

Answer 6

positive, negative

Question 7

repressors are (negative/positive) control

Answer 7

negative

Question 8

activators are (negative/positive) control

Answer 8

positive

Question 9

class (I, II, III) genese make rRNA

Answer 9

class I

Question 10

class (I, II, III) genese make mRNA, snRNA

Answer 10

class II

Question 11

class (I, II, III) genese make tRNA, snRNA

Answer 11

class III

Question 12

-TATA
-iniatiator
-TATA less and initiator less
are all (promotor/inhibitor)

Answer 12

promotors

Question 13

in the TATA less and initaor less what is there instead for the promoters to recognize?

Answer 13

GC island

Question 14

pol (i. ii) it has silencers that repress transcription

Answer 14

II

Question 15

GTF binds to TATA and INR and positons RNA pol (I, II, III)

Answer 15

II

Question 16

out of all the TFII which one has helicast ATPAase activity ?

Answer 16

TFIIH

Question 17

how many TAFs are there
A)15
b)14
c)13

Answer 17

14

Question 18

TBP is (assymetrical/symmetrical) in its tertiary structure. 
Either side of the protein reaches into the (minor/major) grove of the DNA to bind and distort promoter DNA structure.

Answer 18

symmetrical, minor groove

Question 19

whats the structore of activator that binds to a specific DNA sequence?

Answer 19

itsa modular protein

Question 20

How do activator communicate with pol II?

Answer 20

uses co activator

Question 21

what type of motif do homeobox protiens have (helix-turn-helix/helix-loop-helix)

Answer 21

helix-turn-helix

Question 22

name the four types of motifs that DNA binding protein can have

Answer 22

HTH, HLH, ZN finger, leuzine sipper

Question 23

T/F Hox genes control

• morphology of vertebra
• segmentation of hindbrain
• digits of the limbs

Answer 23

T

Question 24

How many human genes are there?
A)25,000
B)30,000
C)40,000

Answer 24

25,000

Question 25

T/F Gene control is dont on a gene-specific or cell specific manner

Answer 25

T

Question 26

Human disease is linked to pol (I, II, III)

Answer 26

II

Question 27

VHL is a ____

Answer 27

genetic disorder

Question 28

VHL binds to subunits (b/C/A/D)

Answer 28

B and C

Question 29

elongin complex (decreases/increases) the rate of trancription elongation

Answer 29

increases

Question 30

T/F Mutations in VHL protein prevent its binding to elongin

Answer 30

T

Question 31

loss of VHL lead to (deactivation/activiation) of angiogneic pathways

Answer 31

activation

Question 32

VHL mutation -> prevents binding of elongin BC–> and thus inhibits the formation of active ubiquitin ligase00> HIF is not degraded –> tumor growth is sustained

Answer 32

T

Question 33

GH stands for ?

Answer 33

growth hormone

Question 34

GH is dependent on binding of trancription factor (VHL/Pit-1)

Answer 34

pit-1

Question 35

How many amino acids are there in Pit-1
A)291
b)391
c)491

Answer 35

291

Question 36

(VHL/Huntington’s disease) is an inherited neurodegenerative disease, progressive deterioratoin of motor and cognitive abilities

Answer 36

Huntington’s disease