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MCBM > 11-4-13 Replication and Telomeres > Flashcards

11-4-13 Replication and Telomeres Flashcards

1
Q

T/F mammalian and E. coli replicaiotn processes are similar

A

T

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2
Q

T/F all component of repliaciont and mutations in genes responsible for replication have been characterized in yeast

A

T

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3
Q

-similar replication fork geometry
-mulitprotein replication machine
are the same in (yeast/e coli./mammalian)

A

e.coli and mammalian

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4
Q

Genome- 4.64 million basepairs circular DNA
Single origin of replication
Same polymerase for leading and lagging strand synthesis
describes (e.coli/mammalian)

A

e. coli

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5
Q

23 pairs of linear chromosomes- 3.2 billion basepairs
Multiple origins of replication (~1000)
Same or different polymerases for leading and lagging strand synthesis
describes (e.coli/mammalian)

A

mammalian

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6
Q

single origin of replication

-describes (ecoli/mammalian)

A

e.coli

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7
Q

same polymerase for leadig and lagging strand

-describes (ecoli/mammalian)

A

e.coli

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8
Q

multiple origins of replication

-describes (ecoli/mammalian)

A

mammalian

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9
Q

same or different polymerases for leading and lagging strand synthesis
(e.coli/mammalian)

A

mammalian

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10
Q

RNaseH degrades (DNA/RNA)

A

RNA

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11
Q

T/F okasaki fragments are smaller than E. coli

A

T

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12
Q

polymerase (alpha/beta/gamma) is primase

A

alpha

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13
Q

polymerase (alpha/beta/gamma) is mitochondrial replication

A

gamma

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14
Q

polymerase (alpha/beta/gamma) is repair

A

beta

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15
Q

polymerase sigma and e are both ____

A

nuclear replication

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16
Q

(e.coli/mammalian) replication is cirlcular

A

e.coli

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17
Q

(e.coli/mammalian) replication is linear

A

mammalian

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18
Q

which end will shorten with each replication cycle?

5’ or 3’

A

5’

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19
Q
  • coding sequences may be eventualy lost
  • senescence or death signal may be triggered
  • -these are both consequence of what?
A

shortening of the 5’ end after each replication cycle/

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20
Q
  • origin of repliication
  • centromere
  • telomere
  • -these are all requirement for what
A

chromosome replication

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21
Q

(centromere/teleomore) seal the ends of chromosomes

A

telomere

22
Q
  • avoid undesirable fusion
  • aboid aberrant recomination
  • –(centromere/teleomere)
A

telomere

23
Q

(centromere/teleomore) attach chromosomes to nuclear envelope

A

telomere

24
Q

telomeres have (sepa/hexa)meric repeats

A

hexameric

25
Q

___ makes teomeric repeats

A

telomrase

26
Q

what is a telomerase?

A

protein + RNA

27
Q

what type of activity does the protein portion of the temoerase do?

A

reverse transcriptase

28
Q

telomerase is (DNA/RNA) dependent DNA polymerase

A

RNA

29
Q

which end does telomerase extend?

A

3’

30
Q

telomere repeats from G (quartets/triplets)

A

quartets

31
Q

what is the name of the tail made by the telomerase (A tail/G tail)

A

G-tail

32
Q

(somatic/germ) cells have detectable activity

A

germ

33
Q

(somatic/germ) cells have no detecable activiyt

A

somatic

34
Q

fibroblast from the (young/elderly) have shorter fibroblasts

A

elderly

35
Q
  • replicative sensecense
  • apoptosis
  • -are induced by (long/short) telomeres
A

short

36
Q

T/F in human cnacer there is more telomerase activity than in normal tissue

A

T

37
Q

GRN163L and G-quadruplex stabilizing agens are thoguh to (activate/block) the replicative portention of cancer cells

A

block

38
Q

Viruses (have/don’t have) a cell structure or metabolism, but they (are/aren’t) capable of reproducing viruses

A

dont have, aren’t

39
Q

____ is an inert virus particle outside of teh cell host

A

virion

40
Q

virus genomes are (single/double) DNA and RNA

A

single double

41
Q

T/F viral nucleic acids are replicated only in host cells using host cell machinery

A

T

42
Q

Replication of viruses involves : what three things?

A

synthesis of genome, translation , transcription

43
Q

Viral genomes (are/aren’t) variable in size organization and replication patterns

A

are

44
Q

HIV has
A) 9749 nucleotides 9 genes 15 proteins
B) 9749 nucleotides 15 genes 9 proteins

A

A

45
Q

AZT inhibits (reverse transcriptiase/integrase)

A

reverse transcriptase

46
Q

bacterial gyrase inhibitors are used in (antibiotics/chemotherapy)

A

antibiotics

47
Q

topoisomerase inhibitors are used for (antibiotics/chemotherapy)

A

chemotherapy

48
Q

5-Florouracil inhibitor of (DNA replication/reverse transriptase) used for cancer chemotherapy

A

DNA replication

49
Q

5-florouriacil is an analogue for uracil and ___

A

thymine

50
Q

Capecitabine is a orally administered chemotherapeutic agent which is converted to (5-florouracil/AZT)

A

5-Florouracil

MCBM (15 decks)

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