1.1: The Cardiovascular System Flashcards

1
Q

What is the cardiovascular system?

A
  • the body’s transport systems
  • it includes the heart and the blood vessels.
  • during exercise, an efficient cardiovascular system is extremely important as the heart works to pump blood through the various blood vessels to deliver oxygen to the working muscles and gather waste products
  • it’s also responsible for transporting heat (a by-product of exercise) to the skin so a performer can cool down
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2
Q

What are the chambers of the heart?

A
  • the heart is divided into two parts by a muscular wall called the septum and each part co rains two chambers - an atrium or a ventricle
  • right atrium
  • left atrium
  • right ventricle
  • left ventricle
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3
Q

What are atria?

A
  • are smaller than the ventricles as they push the blood down into the ventricles. This doesn’t require much force so they have thinner muscular walls.
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4
Q

What are ventricles?

A
  • the ventricles have much thicker muscular walls as they need to contract with greater force in order to push blood out of the heart.
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5
Q

What are the blood vessels?

A
  • vena cava: brings deoxygenated blood back to the right atrium
  • pulmonary vein: delivers oxygenated blood to the left atrium
  • pulmonary artery: the pulmonary artery leaves the right ventricle with deoxygenated blood
  • aorta: leaves the left ventricle with oxygenated blood.
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6
Q

What are the valves in the heart?

A
  • four main valves in the heart that regulate blood flow by ensuring it moves in only one direction. They open to allow blood to pass through and then close to prevent back flow.
  • bicuspid valve: located between the RA and RV
  • bicuspid valve: located between the LA and LV
  • *
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7
Q

Key term - myogenic:

A
  • the capacity of the heart to generate its own impulses
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8
Q

Key term - sinoatrial node (SAN or SA node):

A
  • a small mass of cardiac muscle found in the wall of the right atrium that generates the heartbeat. - It is more commonly called the pacemaker
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9
Q

Key term - atrioventricular node (AVN or AV node):

A
  • this node relays the impulse between the upper and lower sections of the heart.
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10
Q

Key term - systole:

A
  • when the heart contracts
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11
Q

Key term - bundle of his:

A
  • a collection of heart muscle cells that transmit electrical impulses from the AVN via the bundle branches to the ventricles.
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12
Q

Key term - purkinje fibres:

A
  • muscle fibres that conduct impulses in the walls of the ventricles.
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13
Q

What is the Cardiac conduction system:

A
  • the cardiac conduction system is a group of specialised cells located in the wall of the heart which send electrical impulses to the cardiac muscle, causing it to contract.
  • when the heart beats, the blood needs to flow through it in a controlled manner, in through the atria and out through the ventricles.
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14
Q

Cardiac conduction system:

A
  • heart muscle is described as being myogenic as the brat starts in the heart muscle itself with an electrical signal in the sinoatrial node (SAN).
  • this electrical impulse then spreads through the heart in east us often described as a wave of excitation.
  • from the SAN the electrical impulse spreads through the walls of the atria, causing them to contract and forcing blood into the ventricles.
  • the impulse then passes through the atrioventricular node (AVN) found in the atrioventricular septum. The AVN delays the transmission of the cardiac impulse for approximately 0.1 seconds to enable the atria to fill contract before ventricular systole begins.
  • the electrical impulse then passes down through some specialised fibres which form the bundle of His. This is located in the septum separating the two ventricles.
  • the bundle of His branches out to two bundle branches and then moves into smaller bundle called purkinje fibres which spear throughout the ventricles causing them to contract.
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15
Q

Cardiac conduction system - method:

A
  • SAN
  • atrial systole
  • AVN
  • bundle of His
  • purkinje systole
  • ventricular systole
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16
Q

What is the Autonomic nervous system (ANS)?

A
  • involves the sympathetic and parasympathetic nervous system.
  • the nervous system is made up of two parts;
  • the central nervous system (CNS) - consists of the brain and spinal cord
  • the peripheral nervous system - consists of nerve cells that transmit information to and from the CNS.
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17
Q

Key term - sympathetic system:

A
  • a part of the autonomic nervous system that speeds up heart rate.
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18
Q

Key term - parasympathetic system:

A
  • a part of the autonomic nervous system that decreases heart rate.
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19
Q

What is the Cardiac Control Centre (CCC)?

A
  • co-ordinates the CNS and peripheral nervous system and is located in the medulla oblongata - the most important part of the brain as it regulates processes that keep us alive such as breathing and heart rate.
  • sympathetic nervous impulses are sent to the SAN and there is a decrease in parasympathetic nerve impulses so that heart rate increases.
  • the cardiac control centre (CCC) is stimulated by chemoreceptors, baroreceptors and proprioceptors.
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20
Q

What are chemoreceptors?

A
  • tiny structures in the carotid arteries and the aortic arch and they sense chemical changes.
  • during exercise, chemoreceptors detect an increase in carbon dioxide. The role of blood CO2 is important in controlling HR. An increased conc. of CO2 in the blood will have the effect of stimulating the sympathetic nervous system, which means the heart will beat faster.
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21
Q

What are baroreceptors?

A
  • they contain nerve endings that respond to the stretching of the arterial wall caused by changes in blood pressure, they establish a set point for bp. When the set point changes, signals are sent to the medulla.
  • an increase in arterial pressure causes an increase in the stretch of the baroreceptor sensors and results in a decrease in heart rate.
  • a decrease in arterial pressure causes a decrease in the stretch of the baroreceptor sensors and results in an increase in heart rate.
  • at the start of exercise, the baroreceptor set point increases, which is important as the body does not want the heart rate to slow down as this would negatively affect performance, as less oxygen would be delivered to the working muscles.
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22
Q

What are proprioceptors?

A
  • sensory nerve endings located in muscles, tendons and joints that provide information about movement and body position.
  • at the start of exercise, they detect an increase in muscle movement. These receptors then send an impulse to the medulla, which then sends an impulse through the sympathetic nervous system to the SAN to increase heart rate.
  • when the parasympathetic nerve simulates the SAN, heart rate decreases.
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23
Q

What is adrenaline?

A
  • a stress hormone that is released by the sympathetic nerves and cardiac nerve during exercise. It stimulates the SAN which results in an increase in both the speed and force of contraction, thereby increasing cardiac output.
  • this results in more blood being pumped to the working muscles so they can receive more oxygen for the energy they need
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24
Q

What is stroke volume?

A
  • ‘the volume of blood pumped out by the heart ventricles in each contraction’
  • during exercise, the need to transport more oxygen to the working muscles means the heart has to work harder.
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25
Q

Factors that stroke volume depends on:

A
  • venous return: this is the volume of blood returning to the heart via the veins. If VR increases, then stroke volume will also increase.
  • the elasticity of cardiac fibres: this is concerned with the degree of stretch of cardiac tissue during the diastole phase (when the heart relaxes to fill with blood) of the cardiac cycle. the more the cardiac fibres can stretch, the greater the force of contraction will be. A greater force of contraction can increase the ejection fraction - the percentage of blood pumped out by the left ventricle per beat. This is Starling’s Law.
  • the contractility of cardiac tissue: the greater the contractility of cardiac tissue, the greater the force of contraction. This results in an increase in stroke volume.
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26
Q

Starling’s Law - simplified:

A
  • increased venous return
  • greater diastolic filling of the heart
  • cardiac muscle stretched
  • more force of contraction
  • increased ejection fraction
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27
Q

What is heart rate (HR)?

A
  • the number of times the heart beats per minute.

- on average, the resting heart rate is approximately 72 beats per minute.

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28
Q

What is cardiac output?

A
  • ‘the volume of blood pumped out by the heart ventricles per minute’.
  • cardiac output (Q) = stroke volume (SV) x heart rate (HR)
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29
Q

Cardiac hypertrophy:

A
  • the thickening of the muscular wall of the heart so it becomes bigger and stronger; also can mean a larger ventricular cavity.
  • this will have an important effect on stroke volume, heart rage and therefore cardiac output.
  • a bigger, stronger heart will allow blood to be pumped out per beat - this leads to a reduction in heart rate as it doesn’t have to best as often.
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30
Q

Bradycardia?

A
  • a decrease in resting heart rate to below 60 bpm.

- oxygen delivery to the muscles improves as there is less oxygen needed for contractions of the heart.

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31
Q

What are the impacts of physical activity and sport on the health of the individual?

A
  • heart disease
  • high blood pressure
  • cholesterol levels
  • strokes
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32
Q

Heart disease:

A
  • coronary heart disease occurs when your coronary arteries, which supply the heart muscle with oxygenated blood, become blocked or start to narrow by a gradual build-up of fatty deposits (atheroma). High blood pressure, lack of exercise, high levels of cholesterol and smoking can all cause atherosclerosis.
  • as the arteries become narrow they are unable to deliver enough oxygen to heart and pain and discomfort occurs - angina.
  • if a fatty deposit breaks off in the coronary artery it can cause a blood clot which results in a blockage forming - this can cut off the supply of oxygenated blood to the heart muscle resulting in a heart attack.
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33
Q

What impact does exercise have on heart disease?

A
  • exercise keeps the heart healthy and more efficient.
  • it can pump more blood around the body as exercise makes the heart bigger and stronger resulting in an increase of stroke volume.
  • regular exercise can also maintain the flexibility of blood vessels, ensuring good blood flow, normal blood pressure and low levels of cholesterol.
34
Q

High blood pressure:

A
  • high blood pressure is the force exerted by the blood against the blood vessel wall. This pressure comes from the heart as it pumps the blood around the body.
  • high blood pressure put extra strain on the arteries and heart and if left untreated increases the risk of heart attack, heart failure, kidney disease, stroke or dementia.
35
Q

What impact does exercise have on high blood pressure?

A
  • regular aerobic exercise can reduce blood pressure - it lowers both systolic and diastolic pressure by up to 5-10mmHg which reduces the risk of a heart attack by 20%.
36
Q

Cholesterol levels:

A
  • there are two types of cholesterol:
  • LDL (low density lipoproteins) - transport cholesterol in the blood to the tissues and are classed as ‘bad’ cholesterol as thy are linked to increased risk of heart attack.
  • HDL (high density lipoproteins) - transport excess cholesterol in the blood back to the liver where it is broken down. These are classed as ‘good’ cholesterol as they lower the risk of developing heart disease.
37
Q

What impact does exercise have on cholesterol levels?

A
  • regular physical activity lowers bad LDL cholesterol levels. At the same time it significantly increases good HDL cholesterol levels.
38
Q

Strokes:

A
  • the brain needs a constant supply of oxygenated blood and nutrients to maintain its function. The energy to work all the time is provided by oxygen delivered to the brain in the blood.
  • a stroke occurs when the blood supply to part of the brain is cut off causing damage to brain cells so they start to die. This can lead to brain injury, disability and sometimes death.
  • research has shown that regular exercise can help to lower your blood pressure and maintain a healthy weight which can reduce risks of a stroke.
39
Q

What are types of strokes?

A
  • ischaemic strokes - most common form and occur when a blood clot stops the blood supply.
  • haemorrhagic strokes - occur when a weakened blood vessel supplying the brain bursts.
40
Q

What is cardiovascular drift?

A
  • characterised by a progressive decrease in stroke volume and arterial blood pressure; together with a progressive rise in HR.
  • it occurs during prolonged exercise (after 10 mins) in a warm environment.
  • occurs when we sweat and plasma volume decreases reducing venous return and stroke volume.
  • HR will increase to cool down the body.
  • to minimise CD, it’s important to maintain high fluid consumption before and during exercise.
41
Q

What is the vascular system?

A
  • made up of blood vessels that carry blood through the body. These blood vessels deliver oxygen and nutrients to the body tissues and take away waste products such as CO2.
  • together with the heart and lungs, the blood vessels ensure that muscles have an adequate supply of oxygen during exercise in order to cope with the increased demand for energy.
42
Q

What are the two types of circulation - the vascular system?

A
  • pulmonary: deoxygenated blood from the heart to the lungs and oxygenated blood back to the heart.
  • systemic: oxygenated blood to the body from the heart and then the return of deoxygenated blood from the body to the heart.
43
Q

What are the blood vessels?

A
  • the vascular system consists of five different blood vessels that carry the blood from the heart, distribute it round the body and then return it to the heart.
  • heart - arteries - arterioles - capillaries - venules - veins - heart
  • each blood vessel is slightly different in structure.
44
Q

What is the structure of veins?

A
  • they have thinner muscle/elastic tissue layers.

- blood is at a low pressure and they have valves (preventing backflow )and a wider lumen

45
Q

What is the structure of arteries?

A
  • the highest pressure (consequently have more of an elastic outer layer to cope with these fluctuations in pressure)
  • a smaller lumen and a smooth inner layer.
46
Q

What is the structure of capillaries?

A
  • only wide enough to allow one red blood cell to pass through at a given time - this slows down blood flow and allows the exchange of nutrients with the tissues to take place via diffusion.
  • they are also one cell thick resulting in a short diffusion pathway.
47
Q

What is blood pressure?

A
  • the force exerted by the blood against the blood vessel wall and is often referred to as: blood flow x resistance.
  • when the heart contracts, it forces blood out under high pressure. This is called the systolic pressure - the pressure in the arteries where the ventricles are contracting.
    the lower pressure as the ventricles relax is called the diastolic pressure - the pressure in the arteries when the ventricles are relaxing.
48
Q

what is the effect of exercise on blood pressure?

A
  • an increase in systolic pressure due to increased force of contraction/stroke volume
  • decreased diastolic pressure due to vasodilation.
  • different types of exercise and different levels of intensity may have different effects on blood pressure.
  • during exercise, it’s important to increase blood flow through the circulatory system so the muscles receive the oxygen they require. An increase in blood pressure can achieve this.
49
Q

What is venous return?

A
  • the return of blood to the right side of the heart via the vena cava.
  • during exercise, the amount of blood returning to the heart increases. This means that if more blood is being pumped back to the heart, then more blood has to be pumped out, so stroke volume will increase - this is Starling’s Law.
50
Q

What are the venous return mechanisms?

A
  • the skeletal muscle pump: increased muscle contractions compress veins and push blood towards the heart.
  • one-way (pocket) valves: prevents backflow - allows them to flow in one direction.
  • respiratory pump: greater breathing movements alter pressure in thorax compresses veins - assist flow back to heart.
51
Q

Other factors that aid venous return?

A
  • a very thin layer of smooth muscle in the walls of the veins. This helps squeeze blood back towards the heart.
  • gravity helps the blood return to the heart from the upper body.
  • the suction pump action of the heart.
52
Q

Venous return - during exercise and at rest?

A
  • at rest: valûtes and the smooth middle found in veins are sufficient enough to maintain venous return.
  • during exercise: the demand for oxygen is greater and the heart is beating faster, so the vascular system has to help out too. The skeletal muscle pump and the respiratory pump are needed to ensure venous return is maintained.
  • immediately after exercise: we will need to maintain these mechanisms - performing an active cool done will keep the pumps working therefore preventing blood pooling (blood collecting in the veins)
53
Q

Why is it important to maintain venous return during exercise?

A
  • to ensure the skeletal muscles are receiving enough oxygen to meet the demands of the activity.
54
Q

What is the impact of blood pressure on venous return?

A
  • when systolic blood pressure increases, there is also an increase in venous return, and then systolic pressure decreases, there is a decrease in venous return.
55
Q

What is the impact of a pressure gradient on venous return?

A
  • venous return is determined by a pressure gradient.
  • venous pressure (Pv) - right atrial pressure (PRA) / venous vascular resistance (RV)
  • an increase in venous pressure (VP) or a decrease in right atrial pressure, or a decrease in venous resistance (RV), leads to an increase in venous then, whereas increasing right atrial pressure decreases venous return.
56
Q

What happens to oxygen during exercise?

A
  • oxygen diffuses into the capillaries during exercise supplying the skeletal muscles: 3% dissolves into plasma and 97% combines with haemoglobin to form oxyhaemoglobin.
57
Q

What happens when haemoglobin is fully saturated?

A
  • it will carry four oxygen molecules - this occurs when the partial pressure of oxygen in the blood is high.
  • e.g. in the alveolar capillaries of the lungs.
58
Q

What happens at the tissues - oxygen?

A
  • oxygen is released from oxyhaemoglobin due to the lower pressure of oxygen that exists there.
  • the release of oxygen from oxyhaemoglobin to the tissues is referred to as oxyhaemoglobin dissociation.
59
Q

What happens in the muscle - oxygen?

A
  • oxygen is stored by myoglobin.

- this has a high affinity for oxygen and will store the oxygen for the mitochondria until it is used by the muscles.

60
Q

Plasma definition:

A
  • the fluid part of blood (mainly water) that surrounds blood cells and transports them.
61
Q

Haemoglobin definition:

A
  • an iron-containing pigment found in red blood cells, which combines with oxygen to form oxyhaemoglobin.
62
Q

Myoglobin definition:

A
  • often called ‘muscle haemoglobin’
  • it is an iron-containing muscle pigment in slow-twitch muscle fibres which has a higher affinity for oxygen than haemoglobin.
  • it stores the oxygen in the muscle fibres which can be used quickly when exercise begins.
63
Q

Mitochondria definition:

A
  • the centres in the muscle where aerobic respiration takes place.
64
Q

What is the oxyhaemoglobin dissociation curve?

A
  • helps us to understand how haemoglobin in our blood transports and releases oxygen
  • the curve represents the relationship between oxygen and haemoglobin.
65
Q

What does the oxyhaemoglobin dissociation curve show?

A
  • in the lungs there is almost full saturation or haemoglobin but at the tissues the partial pressure of oxygen is lower.
  • haemoglobin gives up 23% of its oxygen to the muscles and therefore is no longer saturated. During exercise this needs to increase and occur faster, so a bigger percentage of oxygen is released from the haemoglobin.
66
Q

What is the Bohr shift?

A
  • when an increase in blood carbon dioxide and a decrease in pH results in a reduction of the affinity of haemoglobin for oxygen.
67
Q

What are the three factors responsibly for the increase in the dissociation of oxygen form haemoglobin?

A
  • increase in blood temperature: when blood and muscle temperature increases during exercise, O2 will dissociate from haemoglobin more readily.
  • partial pressure of carbon dioxide increases: as the level of blood CO2 increases during exercise, oxygen will dissociate faster from haemoglobin.
  • pH: more CO2 will lower the pH in the blood causing oxygen to dissociate from haemoglobin more quickly.
68
Q

The redistribution of blood - during exercise:

A
  • the skeletal muscles require more oxygen so more blood needs to be redirected to them in order to meet this increase in oxygen demand. The redirecting of blood flow is called the vascular shunt mechanism.
  • the
69
Q

Why shouldn’t athletes eat less than an hour before compétition?

A
  • the redirection of blood flow to the working muscles means that sports performers should ensure they don’t eat less than an hour before competition.
  • a full gut would result in more blood being directed to the stomach instead of of the working muscles - this would have a detrimental effect on performance as less oxygen is being made available.
70
Q

Where is blood needed the most?

A
  • blood flow to the brain must remain constant to ensure brain function to ensure brain function is maintained as the brain needs oxygen for energy.
  • more blood needs to go to the heart as the heart muscle needs oxygen for energy to best faster and more blood goes to the skin because energy is needed to cool the body down.
71
Q

How are blood pressure and blood flow controlled?

A
  • the vasomotor centre in the medulla oblongata of the brain.
  • chemoreceptors stimulate the vasomotor centre encoch will redistribute blood flow through vasodilation and vasoconstriction.
72
Q

What is vasodilation?

A
  • the widening of the blood vessels to increase the flow of blood into the capillaries.
  • during exercise: more oxygen is needed at the working muscles so vasodilation will occur in the artérioles supplying these muscles, increasing blood flow and brining in oxygen
73
Q

What is vasoconstriction?

A
  • the narrowing of the blood vessels to reduce blood flow into the capillaries.
  • during exercise: will occur in the artérioles wsuplltint non-essential organs such as the intestines and liver.
74
Q

Redistribution of blood - sympathetic nerves:

A
  • when sympathetic stimulation increases, vasoconstriction occurs and blood flow reduces so it can be redistributed to other parts of the body such as the muscles during exercise.
  • when sympathetic stimulation decreases, vasodilation occurs and increases blood flow to that body part.
75
Q

What are pre-capillary sphincters?

A
  • aid blood redistribution
  • are tiny rings or muscle located at the opening of capillaries
  • when they contract, blood flow is restricted through the capillary and when they relax, blood flow is increased.
76
Q

pre-capillary sphincters - during exercise:

A
  • the capillary networks supplying skeletal muscle will have relaxed pre-capillary sphincters to increase blood flow and therefore saturate the tissues with oxygen.
77
Q

Why is the redistribution of blood important?

A
  • increases the supply of oxygen to the working muscles
  • removes waste products from the muscles, e.g. CO2 and lactic acid.
  • ensures more blood goes to the skin during exercise to regulate body temperature and get rid of heat through radiation, evaporation and sweating.
  • directs more blood to the heart as it is a muscle and requires extra oxygen during exercise.
78
Q

What is arterio-venous difference?

A
  • the difference between the oxygen content or the arterial blood arriving at the muscles and the venous blood leaving the muscles.
79
Q

Arterio-venous difference - at rest:

A
  • the arterio-venous difference is low as not much oxygen is required by the muscles.
80
Q

Arterio-venous difference - during exercise?

A
  • much more oxygen is needed from the blood for the muscles so the arterio-venous difference is high.
  • the increase will affect gaseous exchange at the alveoli so more oxygen is taken in and more CO2 is removed.