11-26 L3 Bone marrow transplant

Question 1

What are the sources of stem cells in clinical practice?

Answer 1

• Bone marrow
• Mobilized peripheral blood
• Placental and umbilical cord blood
• Liver of the human (fetus liver)

Question 2

Sources of stem cells

• Autologous
• Allogeneic
• Syngeneic

Answer 2

• Autologous: BM from self
• Allogeneic (BM from another person)
• Syngeneic: BM from twin

Question 3

Why is HLA-typing important?

name 2 disease we worry about

Answer 3

the greater teh HLA-mismatch the greater the severity of :

• Graft rejection
• Graft-vs-host disease

Question 4

What is the porbability of finding an HLA-match?

• sibling
• Parents
• Grandparents
• Unrelated donor

depends upon ethinc background

Answer 4

• Sibling: 25%
• Parents: 2%
• Grandparents: <1%
• Unrelated donor: 1:20k

Question 5

define

Apheresis

Answer 5

removal or the withdrawal of something (used for collection of peripheral blood)

Question 6

Define 2 cord collection methods

Answer 6

• Collection after delievery of the placenta
• Collection while the placenta is still in utero

Question 7

What are the 3 sites of GVHD?

Answer 7

• Skin
• Gut
• Liver

Question 8

Why did CML decrease significantly in terms of prevelance?

Answer 8

this was due to gleevec

decreased in 2000’s

Question 9

What is the #1 indication for hematopoietic stem cell transplant in:

• Autologous
• Allogeneic

Answer 9

• Autologous: Multiple myeloma
• Allogeneic: AML