11-21 L1 WBC Disorders

Question 1

What are the normal ranges for adult wbc

• WBC
• PMN
• Band
• Lymph
• Mono
• Eos
• Baso

Answer 1

• WBC (4-10K)
• PMN (36-75%)
• Band (2%)
• Eos (0-5%)
• Baso (0-2%)
• Lymph (20-50%)
• Mono (3-8%)

Question 2

How many days does it take after chemo to see neutrophil maturation?

Answer 2

12-14 days

Question 3

ANC

• calc
• ranges

Answer 3

• calc: ANC = WBC x % (PMNs + bands)/ 100
• Mild neutroppenia ANC 1000-15000
• Moderate neutropenia ANC 500-1000
• ANC <5000 sever neutropenia
• AA: lower normal neutrophil counts (1k-2k)

Question 4

Neutropenic fever

• ANC
• Temp
• emergency?
• treatment

Answer 4

• ANC <500
• Fever >101
• only ture oncologic emergency
• Cefepime/ceftazidime

Question 5

cyclin Neutropenia

• days
• inheritances
• syptomes
• treatment

Answer 5

• 21 day cycle
• autosomal dominant
• fever, ulcers
• G-CSF

Question 6

CHS

Chediak-higashi syndrome

• mechanism
• symptoms
• treatment

Answer 6

• NOD (NADPH oxidation deficieny) cannot produce active oxygen
• symptoms: oculocutaneous albinism, photophobia, sun sensitivty, neuropathy, infections (esp Staph aureus)
• Tx: Bone marrow transplant

Question 7

PHA

Pelger-Huet Abnormality

• Inheritance
• histo presentation

Answer 7

• Autosomal dominant
• hypo-segmented neutropenia

Question 8

Eosinophilia

NCAAP

Answer 8

• Neoplasm: Hodgkins disease, ovarian cancer
• Allergy/asthma
• Addison’s disease
• Collagen vascualr disaese (marfan’s syndrome)
• Parasites