11-20 L2 Lymphoma

Question 1

Which is the most common form of lymph node hyperplasia?

Answer 1

Follicular hyperplasia

Question 2

Paracortical hyperplasia

Answer 2

• paracortical zone (t-cell predominant areas)
  *

Question 3

Granulomatous lymphadenitis

• necrotizing
• non-necrotizing

Answer 3

• nectrotizing
  
  • cat scratching, tularemia, LGV, Tb, fungus, brucellosis
• non-nectrotizing
  
  • sacroidosis, early TB, early fungal infection

Question 4

Lymphoma

Answer 4

Hematologic malignancies resulting from clonal proliferation of lymphoid cells

Question 5

Difference b/t hyperplasia and lymphoma

Answer 5

• Hyperplasia
  
  • preserved architecture
  • polyclonal
• Lymphoma
  
  • no recognized architecture
  • monoclonal

Question 6

Lymphoma

• Benign
• Malignant

Answer 6

• Benign
  
  • small (<2 cm)
  • moveable
• Malignant
  
  • large (>2cm)
  • fixed

Question 7

describe the translocation of the following diseases

• Follicular lymphoma
• Burkitt leukemia/lymphoma
• Mantle cell lymphoma
• Anaplastic large cell lymphoma

Answer 7

• FL: t(14:18)
• BL: t(814)
• MCL: t(11,14)
• ALCL: t(2,5)

Question 8

differnece between

HL & NHL

Answer 8

• HL
  
  • almost always nodal
  • reed stalmen cells
• NHL
  
  • extranodal
  • absent

Question 9

Non hodgkin lymphomas

define the major two class

Answer 9

• B-cell
  
  • CD5, or 10
• T-cell
  
  • CD4, 8

Question 10

What is a precursor for T-cell neoplasms

Answer 10

• often presents w/ l_arge mediastinal mass_

Question 11

Define the 5 types of NHL B-cells

FMMD

Answer 11

• Folicular lymphoma
• Mantle lymphoma
• MALT lymphoma
• Diffuse large B-cell lymphoma

Question 12

what is the major difference b/t

follicular hyperplasia and follicular lymphoma

Answer 12

immunohistochemisty:

• Follicular hyperplasia
  
  • BCL-2 neg in germ centers
• Follicular lymphoma
  
  • BCL-2 positive in germ centers

Question 13

Mantle Lymphoma

• up reg of what protein
• translocation
• immunophenotype

Answer 13

• Cyclin D is upregulated
• t(11,14)
• CD5+

Question 14

MALT lymphoma

associated with what bacteria

what type of lesion is seen

Answer 14

• H. pylori bacteria
• lymphoepithelial lesions

Question 15

Diffuse large B-cell lymphoma

• general feature
• histological feature
• good prognosis
• bad prognosis

Answer 15

• most common form of aggresive lymphoma in adults
• mitocit figures, CD 20
• Good prognosis: BCL2-
• Bad prognosis: BCL2+

Question 16

Burkitt lymphoma

• virus assoc
• immunohisto
• translocation
• common feature

Answer 16

• EBV
• CD10+
• t(8,14)
• ki-67 proliferation marker >98%

Question 17

HL

id the 2 types

Answer 17

• cHL (classical hodgkin lymphoma)
• NLPHL (nodular lymphocyte predominant hodgkin lymphoma)

Question 18

cHL

Nodular sclerosis

Answer 18

• young adults
• mediastinum
• Histologic triad
  
  • Nodules of lymphs
  • Collagen bands
  • Hodgkins cells

Question 19

NLPHL

• assoc immune stain
• histological appearance

Answer 19

• CD 20, CD3
• Popcorn cells
  
  • Rosetting of CD-2 positive T cells around LP cells