11-21 L2 Bone marrow erythropoiesis

Question 1

Reticulocytes amt in RBCs

Answer 1

normally constitue about 0.8-1% of RBCs

Question 2

WHat is the receptor for erythropoietin (Epo)?

Answer 2

CFU-E

Question 3

WHere does the erythroblast maturation and division occur in macrophage cytoplasm

Answer 3

eryhtroblastic islands

Question 4

What is considered the beginning of hemoblobin synthesis

Answer 4

basophilic erythroblas–> polychormatophilc erythroblast

Question 5

What is the role of WBC in RBC synthesis?

Answer 5

• supports differentiation and enucleation
• DNAse II is required to digest extruded nuclei

Question 6

What 3 factors regulated hemopoiesis

Answer 6

• humoral factors w/in and outside marrow
• contact w/stromal cells
• extracellular matrix secreted by stromal cells

Question 7

What is used to stimulated neutrophilic production after chemotherapy?

Answer 7

• G-CSF
• also it moblizes HSC from the marrow to peripheral circulation for BMT

Question 8

describe polycythemia

Answer 8

primary compenstaion device for living at high altitude.

• The reticuloctye count (in teh pt’s effort to get polycythemic increases to about 5% in the first week after moving to high altitude*
• during this period the hematocrit steadily increases after acclimatization, however the erticulocyte count is normal and the hematocrit remainshigh*.