101

Question 1

Asthma symptoms

Answer 1

shortness of breath
wheezing

Question 2

Asthma phases

Answer 2

2
immediate - peak flow drop - obstruction becomes evident/ antigen challenge

late phase

Question 3

Asthma - inflammation = leads to

Answer 3

1. Airway obstruction
2. Bronchospasm [ AHR = airway
   hyperresponsiveness]
3. Airway remodelling

Question 4

difference between normal and asthmatic bronchioles

Answer 4

increased airway resistance decreases alveolar ventilation

Question 5

mucous plugging and hyperinflation

Answer 5

inspiration - bronchus/ mucus / alveolus

Question 6

physiology in asthma

Answer 6

during attack - further constriction of airway
bronchiole muscles contract
difficult to breath out and in

detect changes in airways - peak flow + spirometry

Question 7

Which receptors are in the smooth muscles in airways?

Answer 7

Biological - “right target”
Chemical - “right target binding site”

Nor-adrenaline = relaxes airway/ dilatate smooth muscles

Question 8

salbutamol BINDS to receptor >

Answer 8

activates G protein

splits b and a + GTP

Question 9

what does a + GTP bind to?

Answer 9

effector - adenylyl cyclase

uses ATP