10/1: Radiation Biology pt.2

Question 1

This is a collection of signs and symptoms following acute whole-body radiation exposure

Answer 1

Acute radiation syndrome

Question 2

What is the sublethal exposure?

Answer 2

<2 Gy

Question 3

What is lethal exposure?

Answer 3

2-8 Gy

Question 4

What is the supra-lethal exposure?

Answer 4

> 8 Gy

Question 5

What are the stages in acute radiation syndrome?

Answer 5

Prodromal period
Hematopoietic syndrome
Gastrointestinal syndrome
CNS and Cardiovascular syndrome

Question 6

what is the most severe effect from hemopoeitic syndrome?

Answer 6

sepsis

Question 7

What stage of the acute radiation syndrome is NON-LETHAL?

Answer 7

Prodromal period

Question 8

What is the Gy in the prodromal period?

Answer 8

<2

Question 9

What is the Gy in the hematopoietic syndrome?

Answer 9

2-10 Gy

Question 10

What is the Gy in the Gastrointestinal syndrome?

Answer 10

10-100 Gy

Question 11

In prodromal syndrome, when do the symptoms resolve?

Answer 11

After a few weeks

Question 12

What occurs in hematopoietic syndrome?

Answer 12

Irreversible injury to the spleen and bone marrow that causes loss of circulating peripheral blood cells

Question 13

This is extensive injury to the basal lamina epithelial cells of the intestine

Answer 13

Gastrointestinal syndrome

Question 14

How fast do you die from gastrointestinal syndrome?

Answer 14

3-5 days

Question 15

With damage to the CNS and cardiovascular syndrome, how fast is death?

Answer 15

Few minutes to 48 hours

Question 16

What is the most lethal stage of acute radiation syndrome?

Answer 16

CNS and cardiovascular syndrome

Question 17

What treatment will provide the optimum treatment?

Answer 17

Combination of surgery, radiation, chemotherapy

Question 18

What dose to treat solid tumors?

Answer 18

60-80 Gy

Question 19

What dose to treat lymphomas?

Answer 19

20-40 Gy

Question 20

What dose to treat intraoral cancer?

Answer 20

50 Gy

Question 21

1 Gy = _____ microSv

Answer 21

1 million

Question 22

This is when the total dose is divided into multiple small doses to provide greater care

Answer 22

Fractionation

Question 23

Is it better to have multiple small doses or one large dose?

Answer 23

Multiple small

Question 24

What is the radiation effect on the mucosa?

Answer 24

Mucositis
2nd infections

Question 25

What is the radiation effect on taste buds/oral cavity?

Answer 25

Lost of taste

Question 26

What is the term for loss of taste?

Answer 26

Hypogeusia

Question 27

What is the radiation effect on salivary glands?

Answer 27

Xerostomia

Question 28

What is the radiation effect on teeth?

Answer 28

Lack of development
Radiation caries

Question 29

What is the radiation effect on bone?

Answer 29

Osteoradionecrosis

Question 30

What is the radiation effect on muscle?

Answer 30

Fibrosis

Question 31

What kind of teeth are resistant to direct effects of radiation exposure?

Answer 31

Adult teeth

Question 32

If the radiation precedes calcification, then

Answer 32

Tooth bud will be destroyed

Question 33

If the radiation is after calcification, then

Answer 33

Teeth will malform, slow growth

Question 34

What kind of radiation causes radiation caries?

Answer 34

Indirect

Question 35

Bone osteoradionecrosis is primarily due to

Answer 35

Vasculature
Marrow affecting vascular and hematopoietic elements

Question 36

Fibrosis can result in

Answer 36

Contracture and trismus in the muscles