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002 - Virology > (09) Arteriviridae > Flashcards

(09) Arteriviridae Flashcards

1
Q

The four kinds of arteriviridae (which are of the order nidovirales)

  1. Porcine Reproductive and Respiratory Syndrome Virus
  2. Equine Arteritis Virus
  3. Simian Hemorrhagic Fever Virus
  4. Lactate Dehyrdogenase-elevating Virus

*SHE IS GIVING US SLIDES ON LAST TWO BUT DOESN:T EXPECT US TO KNOW ABOUT THEM

A
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2
Q

(Characteristics of Arterivirus)

  1. Enveloped or no?
  2. smooth or rough?
  3. shape?
  4. Has a tropism for what?
A
  1. enveloped
  2. smooth
  3. spherical
  4. macrophage
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3
Q

(Genome)

  1. genetic substance?
A
  1. linear, single stranded + sense RNA (has 5’cap and Poly A tail)

(it immediately starts replicating non-structural proteins then moves on to genome)

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4
Q

(Genome organization)

  1. nonstructural part - has own what to provide proteins for replication?
  2. Structural - has overlapping what?
A
  1. proteases
  2. reading frames - allows for more proteins with less info
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5
Q

(Characteristic of Arterivirus)

  1. HAve restricted host range - are they zoonotic?
A
  1. no
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6
Q

(Characteristics of Arteriviruses)

  1. How transmitted?
  2. do they mutate alot?
  3. Why is it important that they infect macrophages?
  4. Do they causes persistent/asympotmatic diseases or severe/fatol ones?
A
  1. contact/aerosol
  2. yep (infidelity of polymerase/ recombination)
  3. get past immune responses
  4. can be either
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7
Q
A

D

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8
Q

(PRRSV)

(Porcine Reproductive and Respiratory Syndrome Virus)

  1. How many genotypes?
  2. endemic in most swine producing regions worldwide
A
  1. 2
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9
Q

(PRRSV)

just read through these

A
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10
Q

PRRSV disease

  1. Respiratory Disease in pigs of all ages - most severe in what though?
  2. Reproductive disease in pregnant sows - worst when?
  3. weaken defenses against secondary infections?
A
  1. growing pigs
  2. third trimester (abortions, stillbirths, mummified piglets, weak piglets)
  3. yes
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11
Q

give this a look

A

and this

but don’t remember any of these

she just wants us to know that there can be more than one pathogen at once

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12
Q

(Route of PRRS)

basically remember that it goes where pigs go - established by contact

A
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13
Q

(PRRSV transmission)

  1. stability in environment?
  2. Aerosol transmission documented over what distance?
A
  1. relatively unstable (enveloped), can survive in cold
  2. 9 km
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14
Q

(PRRSV diagnosis)

just read this - sorry seems like a waste of time to ask a bunch of questions about these when

A
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15
Q

(Tools for control and elimianation of PRRS)

  1. What are the two ways to combat PRRS?
A
  1. management and immunity
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16
Q
  1. What are the best condidtions for PRRSV virus to spread?
  2. What are put up to reduce spread?
A
  1. cold moist air
  2. putting up big filters at points of entrance
17
Q

(PRRSV vaccines)

  1. use killed or modified?
  2. Which induces better protection
  3. Can MLV persist in pigs and be transmistted?
  4. Can it revert to virulence?
A
  1. both are used
  2. MLV
  3. yes
  4. maybe
18
Q
A
19
Q
  1. Is PRRSV amenable to eradication?
A
  1. not really - it takes a lot money to do this and a lot of compliance
  2. Pigs immune system can eliminate PRRSV - but it takes a long time
20
Q

(Equine Arteritis Virus)

(EAV)

  1. What is te tropism for?
  2. then move where?
  3. syptmoms>
  4. worldwide?
A
  1. alveolar macrophages and endothelial cells
  2. draining lymph nodes and systemic
  3. usually asymptomatic
  4. yep
21
Q

(EAV)

  1. Mostly subclinical?
  2. When you do get signs in adult horses what do you get?
  3. what in young foalds?
  4. pregnant mares?
  5. a vascular injuty, increase permeabtiliy, proinflammatory cytokines
A
  1. yes
  2. respiratroy illness
  3. pneumonia
  4. abortion
22
Q

take a look

A
23
Q

(Transmission of EAV)

1-2. What are the two routes of transmission?

  1. What one is the biggest problem?
A
  1. respiratory/aerosol from acutely affected horses
  2. veneral from acutely or chronically infected stallions
  3. the carrier stallions
24
Q

(EAV)

  1. Does infection induce long lasting immunity?
  2. Neutralizing antibodies following infection last how longs?
  3. But - virus still persists where?
A
  1. yes
  2. years
  3. repro tract of carrier stallion
25
Q

(EAV diagnosis)

just read this

lots of economic loss due to EAV!!!

A
26
Q

(EAV control)

  1. important to identify what?
  2. can only breed to what?
A
  1. carrier stallions (test the semen)
  2. immune mares separated from suscpetible
27
Q

(EAV vaccines)

just read this

  1. are there marker vaccines for this?
A
  1. no
28
Q
A

E

29
Q

just read the remaining stuff (didn’t sound like there would be any questions on it)

A
  1. mice
30
Q

know this shit!!!

A

002 - Virology (14 decks)

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