07.1 Dealing With Toxins Flashcards
Sight, smell, saliva and gastric acid are examples of what?
Innate physical immunity.
What are the innate parts of saliva?
Lysozyme
Lactoperoxidase
Complement
IgA
What is it called when there is no acid production?
Achlorhydria
What can happen if a PPI is administered in hospital?
Archlorhydria leading to C Diff infection.
What toxins are specifically resistant to gastric acid?
TB
H Pylori
Enteroviruses
What allows the small intestine to usually remain sterile?
Bile Proteolytic enzymes Anaerobic environment High epithelial turnover Rapid transit
What protects the colon from infection?
Anaerobic environment
Mucus layer
What specialised macrophages remove toxins and waste from the blood and filter them into the bile cannuliculi?
Kupffer cells.
What adaptive defences are there in the gut?
GALT gut associated lymphoid tissue
Where is GALT concentrated?
Tonsils
Peyer’s patches
Appendix
What can cause appendicitis?
Lymphoid hyperplasia at appendix base
Fecoliths
Worms
What are some examples of chemical toxins?
Solvents
Drugs
Metalloids
Metals
What are the main categories of toxins?
Chemical Bacterial Viral Protozoal Worms
