03 - Feline Infectious Peritonitis

Question 1

(FIP)

1. what kind of virus causes?

Answer 1

1. feline coronavirus

ssRNA

Question 2

(FIP)

(path)

1. FIP occurs when what happens to virus?

Answer 2

1. the enterotropic FCoV mutates -> allows FCoV to infect and replicate in macrophages

Question 3

(FIP)

1. seroprevalence for FCoV is high, yet few cats develop FIP

Question 4

(FIP)

(risk factors)

1. young cats at ^ risk
2. multiple cat households
3. anything that causes ^ replication of FCoV in intestine

Question 5

(FIP)

(transmission)

1. how is it transmitted?

Answer 5

1. through oronasal contact with infected feces

(FCoV can survive for 7 weeks in dried feces)

(carriers can shed in feces for 10 months)

Question 6

(FIP)

(Cx)

1. incubation can be weeks to years
2. once FIP develops, progressive and fatal within first 3 to 6 weeks usually

(can result in prolonged illness of about 6 months though)

Question 7

(FIP)

(effusive (wet) form)

1. this type causes what?

Answer 7

1. inflammatory fluid in the abdominal cavity (also possible to get in thoracic cavity but not as common)

Question 8

(FIP)

(noneffusive (dry) form)

1. characterized by what?

Answer 8

1. pyogranulomatous inflammation and necrotizing vasculitis in multiple organs

(meningoencephalitis and myelitis are common -> CNS signs)

Question 9

(FIP)

(dx)

(hematology and serum chemistries)

1. total serum protein and globulins are increased in most cases; albumin commonly decreased.
2. a decreased serum albumin globulin ratio (A:G < 0.8) strongly suggests FIP

Question 10

(FIP)

(dx)

(fluid analysis of effusions)

1. if total protein is greater than 3.5 g/dL with more than 50% globulins, FIP is likely
2. does FIP fluid have a low or high nucleated cell count?

Answer 10

2. low

Question 11

(FIP)

(dx)

(FCoV antibody titers in serum or effusions)

1. if titer low, FIP possible
2. if titer high, FIP probable
3. if titer neg, FIP unlikely
4. RT-PCR can detect FCoV, but doesn’t distinguished mutated from non

Question 12

(FIV)

(dx)

1. what is definitive for confirmation for FIP?

what are the lesions?

Answer 12

1. histopath

vasculitis and pyogranulomatous infalmmation

Question 13

(FIV)

(tx)

1. no tx has been shown to reduce the risk of FIP development in cats with FCoV
2. intereferon may cause remission, but is $$$
3. tx w/ what may cause transient improvement?

Answer 13

3. high-dose corticosteroid

Question 14

(FIP)

1. there is a vx but it sukks

Question 15

(FIP)