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Tox Exam 2 > Zinc phosphide rodenticide poisoning > Flashcards

Zinc phosphide rodenticide poisoning Flashcards

1
Q

Regulation type?

A

RUP

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2
Q

Sources

A

Bait
Secondary (rodents)
Birds-in contaminated food by product carried by rodents
Malicious

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3
Q

Properties

A

Gray-black powder
Acetylene odor (dead fish)
Insoluble in water
Irritant

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4
Q

What it liberates in acidic conditions?

A

Phosphine gas (toxic, flammable and irritant)

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5
Q

Toxicity is enhance by _____ and decrease by _______

A

Gastric acids, vomiting

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6
Q

Acute toxicity is cause by

A

Phosphine gas

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7
Q

Chronic toxicity is cause by

A

Zinc phosphide and phosphine gas

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8
Q

Where are both absorbed?

A

GI tract

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9
Q

Phosphine gas is metabolized and excreted by ___________

A

Lungs

Some excreted in urine

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10
Q

MoA most likely

A

Inhibition of oxidative phosphorylation

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11
Q

Tissues mainly affected are

A

Brain, heart, lungs, liver, and kidneys

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12
Q

Causes irritation of

A

GI and respiratory mucosa

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13
Q

How is the onset?

A

Rapid (minutes to hours)

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14
Q

Clinical signs.

A

Anorexia, vomiting with blood, ^resp. rate and depth, wheezy resps., abdominal pain, dyspnea and death

Cattle: Bloat
Dogs: cns- mad dog running

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15
Q

Death is usually due to

A

tissue anoxia

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16
Q

Lesions

A

Odor of dead fish in stomach contents or vomit
Gastroenteritis
Liver, kidney and lung congestion

17
Q

Lab diagnosis

A 
Zinc phosphide in rapidly frozen stomach content, vomit or bait
^Zinc serum
Metabolic acidosis
Dehydration
Hypocalcemia
18
Q

TX

A

Decontamination and supportive and symptomatic tx

Oral antiacids

19
Q

What do humans need to keep in mind when treating animals with zinc phosphide toxicosis

A

Expired Phosphine Gas from animal can affect humans. Good ventilation when driving the animal to clinic.
Humans detect it at 2ppm and the safe level is 1ppm

Tox Exam 2 (7 decks)

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