Zinc phosphide rodenticide poisoning Flashcards
Regulation type?
RUP
Sources
Bait
Secondary (rodents)
Birds-in contaminated food by product carried by rodents
Malicious
Properties
Gray-black powder
Acetylene odor (dead fish)
Insoluble in water
Irritant
What it liberates in acidic conditions?
Phosphine gas (toxic, flammable and irritant)
Toxicity is enhance by _____ and decrease by _______
Gastric acids, vomiting
Acute toxicity is cause by
Phosphine gas
Chronic toxicity is cause by
Zinc phosphide and phosphine gas
Where are both absorbed?
GI tract
Phosphine gas is metabolized and excreted by ___________
Lungs
Some excreted in urine
MoA most likely
Inhibition of oxidative phosphorylation
Tissues mainly affected are
Brain, heart, lungs, liver, and kidneys
Causes irritation of
GI and respiratory mucosa
How is the onset?
Rapid (minutes to hours)
Clinical signs.
Anorexia, vomiting with blood, ^resp. rate and depth, wheezy resps., abdominal pain, dyspnea and death
Cattle: Bloat
Dogs: cns- mad dog running
Death is usually due to
tissue anoxia
Lesions
Odor of dead fish in stomach contents or vomit
Gastroenteritis
Liver, kidney and lung congestion
Lab diagnosis
Zinc phosphide in rapidly frozen stomach content, vomit or bait ^Zinc serum Metabolic acidosis Dehydration Hypocalcemia
TX
Decontamination and supportive and symptomatic tx
Oral antiacids
What do humans need to keep in mind when treating animals with zinc phosphide toxicosis
Expired Phosphine Gas from animal can affect humans. Good ventilation when driving the animal to clinic.
Humans detect it at 2ppm and the safe level is 1ppm
