Cholecalciferol Rodenticide Toxicosis

Question 1

Other name of cholecalciferol

Answer 1

Vitamin D3

Question 2

Sources of Vit D3

Answer 2

Bait
Poisoned Rodents
Large doses of VitD (multivitamins, feed additive)
Human psoriasis medications
Poisonous plants with VitD analog

Question 3

Example of Plants containing Vit D analog

Answer 3

Day Blooming Jasmine

Turkey Berry

Question 4

What animals are susceptible?

Answer 4

All

Question 5

What animals are more frequently poisoned?

Answer 5

Dogs and cats

Question 6

What animals are more sensitive?

Answer 6

Cats and young animals

Question 7

Predisposing factors for VitD3 toxicosis

Answer 7

Renal Disease
Hyperparathyroidism
Ingestion of high calcium and phosphorus diets

Question 8

Where is it absorbed?

Answer 8

GI tract

Question 9

Metabolized in the _______ by _________ to ____________

Answer 9

liver, hydroxylation, 25-hydroxycholecalciferol (calcidiol)

Question 10

Calcidiol is transported to _____ to be metabolized to ____

Answer 10

kidney, 1,25-dihydrocholecalciferol (calcitriol)

Question 11

Highest concentrations found in

Answer 11

Plasma, liver, kidneys and fat

Question 12

Mainly excreted by

Answer 12

Bile.

VitD canbe excreted in milk in toxic levels

Question 13

MoA

Answer 13

Increases serum calcium by increasin GI absorption, tubular reabsorption and ca resorption.
Deposition of ca in soft tissues and loss of their functions

Question 16

TX

Answer 16

Early decontamination
Reduction of serum ca
Supportive and symptomatic of organ dysfunction

Question 20

What are the lesions of VD3 toxicosis?

Answer 20

Hemorrhagic gastroenteritis

Calcification of soft tissues such as lung, heart, kidney, stomach, intestines and blood vessels

Question 21

Laboratory diagnosis major findings

Answer 21

Hypercalcemia
Hyperphosphatemia
Elevated serum levels of calcidiol and calcitriol
Decrease levels of iPTH