Dipyridil herbicides toxicosis

Question 1

Named the two forms

Answer 1

Paraquat and diquat

Question 2

Whats the regulation?

Answer 2

Paraquat is RUP

Diquat is GUP

Question 3

What are the concentrated and diluted forms used for?

Answer 3

Agricultural use, lawns and gardens

Question 4

Sources

Answer 4

Ingestion

Malicious

Question 5

Properties

Answer 5

Unstable and inactivated by soil and light
Paraquat binds strongly to soil
Caustic to MMs

Question 6

What animals are susceptible

Answer 6

all, specially dogs

Question 7

Toxicity of Paraquat is enhanced by

Answer 7

VitE deficiency
Depletion of tissue glutathione
Oxygen therapy

Question 8

Which one is poorly absorbed in GI tract?

Answer 8

Diquat

Question 9

Where is paraquat absorbed and distributed?

Answer 9

GI tract (20%) skin (10%)

All over body, high [] in lungs

Question 10

Paraquat is excreted within ______ mainly unchanged in _________

Answer 10

24 hours, urine

Question 11

MoA: Reduced by ______ to produce _________, which reacts with _________ to form _____________

Answer 11

NADPH
singlet oxigen
lipids of the membrane
hydroperoxides

Question 12

What are hydroperoxides and what to they cause

Answer 12

Free radicals. Membrane damage, cellular degeneration and necrosis. Specially lung.