Fluroacetate (compound 1080) rodenticide tox

Question 1

Regulation type?

Answer 1

RUP

Question 2

Whats the use of fluroacetate?

Answer 2

Used in LPC (livestock protction collar) collars to prevent coyote preying on sheep and goats

Question 3

Sources

Answer 3

Plants
Accidental
Secondary
Malicious

Question 4

Properties

Answer 4

Odorless
Water soluble
Stable
Degraded by soil microorganisms and plant enzymes
Irritant

Question 5

What animals are most sensitive?

Answer 5

Dogs

Question 6

What animals are resistant?

Answer 6

Birds, followed by rodents.

Question 7

Where is it absorbed?

Answer 7

GI tract, lung and open wounds

Question 8

Distributed ________ without ________ in particular tissues

Answer 8

Throughout the body, accumulation

Question 9

Metabolized by ______ to ________.

Answer 9

Mitochondria, fluorocitrate.

Called lethal synthesis

Question 10

Fluroacetate and fluorocitrate are metabolized ___________ and excreted in ________

Answer 10

Systematically, urine

Question 11

MoA

Answer 11

Fluorocitrate inhibits krebs cycle enzyme aconitase, which converts aconitate to citrate, interfering with energy production and aerobic metabolism
Results in: atp depletion, ^citric and lactic acid (acidosis).

Question 12

What organ’s function are affected the most?

Answer 12

Brain and heart.

Question 13

What are the consequence of citrate accumulation

Answer 13

Binding to serum calcium causing hypocalcemia and heart failure

Question 14

Clinical signs of dogs

Answer 14

CNS stimulation and gi irritation

Question 15

In what animals does cardiac signs predominates

Answer 15

horses

Question 16

Clinical signs of horses ruminants cats and pigs

Answer 16

Cardiac signs and CNS signs

Vocalization in cats

Question 17

lab dx

Answer 17

Chemical analysis (difficult) of rodenticide in vomit and stomach content 
High citrate in kidney or blood. (not dx)

Question 18

tx

Answer 18

Decontamination (Apomorphine no)

Supportive and symptomatic

Question 19

Whats the difference between seizures caused by strychnine and seizures caused by fluroacetate?

Answer 19

Strychnine seizures are externally stimulated and fluoroacetate’s arent.