Zinc

Question 1

____% of intracellular zinc is found inside the nucleus

Answer 1

30-40%

Question 2

best sources of zinc

Answer 2

red meats and seafood

Question 3

what are the 2 major transporters of zinc

Answer 3

1. Zrt

2. Irt-like protein 4 (ZIP4)

Question 4

a mutation in the ZIP4 is known to cause

Answer 4

acrodermatitis enteropathica

Question 5

two families of zinc transporters

Answer 5

1. ZnT family - 10 isoforms

2. ZIP family - 14 isoforms

Question 6

what are the two amino acid transporters of zinc

Answer 6

cysteine and histidine

Question 7

storage of cysteine rich proteins called

Answer 7

metallothionein

Question 8

reduced zinc absorption is _________ with metallothionein formation

Answer 8

directly correlated

Question 9

greater the zinc intake: ____ zinc absorbed

Answer 9

less

Question 10

_____ transports zinc into hepatocytes

Answer 10

ZIP14

Question 11

____ moves zinc out of the body into the intestinal cells and then into the lumen of the GI tract for excretion

Answer 11

ZIP5

Question 12

binds zinc, copper, cadmium, and mercury

Answer 12

metallothionein

Question 13

what are the 7 zinc dependent enzymes

Answer 13

1. carbonic anhydrase
2. alcohol dehydrogenase
3. carboxypeptidase
4. aminopeptidase
5. alkaline phosphate
6. aminolevulinic acid dehydratase (replaces zinc w/ lead)
7. superoxide dismutase (SOD)

Question 14

zinc is a component of the protein _____ (involved in taste acuity)

Answer 14

gustin

Question 15

zinc is needed for structural stability of the storage form of ___ in the granules of _______

Answer 15

insulin

pancreatic B cells

Question 16

zinc deficiency can lead to _____ deficiency

Answer 16

vitamin A

Question 17

______ binds to sites which zinc normally binds (direct inhibitor)

Answer 17

cadmium

Question 18

excess zinc stimulates

Answer 18

thionein synthesis