Carotenoids Flashcards
what are the three most common dietary provitamin A carotenoids
- alpha - carotene
- beta - carotene
- beta - cryptoxanthine
what carotenoid is physiologically important
lycopene
oranges, tangerines, and red bell peppers provide
beta - cyptoxanthine
egg yolks are a rich source of
- lutein
2. zeaxanthin
_____ protects carotenoids from oxidation
vitamin E
too much vitamin E can diminish carotenoid absorption
T
in the enterocyte, beta - carotene is cleaved by using
beta - carotene 15,15’ - monoxygenase
________ transcriptional expression is suppressed when retinoic acid concentrations gets too high
beta - carotene 15,15’ - monoxygenase
what are the 3 routes of metabolism of carotenoids
- cleaved and reduced to form retinol
- packaged and released from the liver in VLDL’s *
- stored in the liver’s stellate cells
in the serum, carotenoids are transported using
VLDLs, LDLs, and HDLs
what is the best carotenoid free radical scavenger
lycopene
____ appears more effective in inhibiting neoplastic transformations than beta - carotene followed by alpha - carotene, and then lycopene
canthaxanthin
carotenoids suppress anti-apoptotic genes in cancer cells and activates pro-apoptiotic genes
T, inhibits 5 alpha - reductase
what immune enhancing functions do carotenoids provide
- increased lymphocytes
- enhanced natural killer cell cytotoxicity
- stimulated neutrophil phagocytic and bacterial killing ability
beta - carotene supplementation can increase cancer risk in smokers, asbestos workers, and chronic alcoholics
T