Z-TPR-Biological Fdn of Behavior Flashcards
Basic functional and structural unit of the ns Have only 1 axon but many dendrites
Neuron
Electrochemical signals of the ns
Action potential
Central cell body of neuron
Soma
Neurons with one dendrite
Bipolar
Neurons with many dendrites
Multipolar
Receive signals in a neuron
Dendrites
Carry action potentials away from the cell body
Axons
Part of neuron that forms connections with target cells
Synaptic knob
Very small gap where chemical messengers are released
Synaptic cleft
Difference between neuron and nerve
Neuron is a single cellNerve is a large bundle of many different axons from many neurons
What is the resting potential?
Electric potential across pm at -70 Millivolts (mV)
What is the overall charge of the interior with respect to exterior of the cell
Negative
What are the 2 primary membrane proteins required to establish resting membrane potential?
na+/k+ ATPase And potassium leak channels
Action potential signal transformed into chemical signal with the release of neurotransmitter into synaptic cleft
Synaptic transmission
Sodium potassium ATPase pumps how many sodiums out and how many potassiums inHow many atp does it hydrolize each time?What form of transport?
3 sodium ions out2 potassiums in1 atp hydrolysisActive
Channels that are open all the time and allow ions to flow across membranes according to gradient
Leak channels
Are neurons only cells w resting membrane potential?
No..all cells have resting membrane potential. Neurons and muscle cells are the only ones who use it to generate action potentials
What makes the cell interiorly negative?
Flow of potassium outside of the cell thru leak channels and 2. Sodium potassium ATPase
A disturbance in the membrane potential where a wave of depolarization of the pm travels along an axon
Action potential
Change in membrane potential from resting membrane -70 mV to a more positive potential
Depolarization
Returns membrane potential to normal after depolarization
Repolarization
Key proteins in propagation of action potentials
Voltage gated sodium channels
What is the threshold potential
-50 mV
When threshold potential is reached what happens to channels
Open fully and sodium flows in cell Depolarizes to about +35 and makes it more positive
Voltage gated channels require what to open
Reach a threshold potential of -50 mV
Factors that produce repolarization
1: voltage gated sodium channels inactivate very quickly after opening. Remain inactivated until resting membrane potential reached2: Voltage gated potassi channels open slowly and potassium goes OUT towards gradient and makes it more negative insideIt overshoots to about -90 mV then closes3. Potassium leak channels and sodium/potassium ATPase continue to function to bring back to -70 (would repolarize membrane alone but takes too long)
More potassium leak channels or potassium leak channels
Mostly potassium leak channels 100:1 ratioMembrane virtually impermeable to sodium
Myelenate neurons in the pns
Schwann cells
Myelinate neurons in the cns
Oligodendrocytes
Would neuron be able to conduct action potential of completely wrapped in myelin?
No. Ions can’t enter or exit where Adonai membrane covered with myelin
Rapid jumping conduction in myelinated axons
Salt story conduction
Periodic gaps in myelin sheath
Nodes of ranvier
Guide neuronal development in cnsRegulate synaptic communication via regulation of neurotransmitter level in cns
Astrocytes
Remove dead cells and debris in cns
Microglia
Produce and circulate csf in cns
Ependynal cells
During action potentials movement of sodium and potassi across membrane thru voltage gated Channels are Passive or active
Passive
Membrane potential all where gradient driving force doesn’t exist (ie no net movement of ions across membrane)
Equilibrium potential
2 phases of the refractory period
Absolute refractory periodRelative refractory period
A neuron can’t fire another action potential no matter how strong depolarization is induced Voltage gate sodium channels inactivatedCan’t open again until membrane potential reaches resting potential
Absolute refractory period
Part of refractory period where neuron can be induced to transmit action potential but depolarization required greater than normal cuz it’s hyperpolarized
Relative refractory period
2 types of synapse
Electrical and chemical
Occur when cytoplasm of 2 cells joined by gap junctionsAP spreads directly from one cell to anotherNot common but important in smooth and cardiac muscle
Electrical synapse
Found at axon ends where they meet target cellAP converted into chemical signal
Chemical synapse
Neuro transmitters bind to what
Ligand gated ion channels
Neurotransmitter released at the neuromuscular junction
Acetylcholine
A neurotransmitter is what if it opens a channel that depolarizes post synaptic membrane
Excitatory
A neurotransmitter is what if it makes the post synaptic membrane more negative or hyperpolarized
Inhibitory
Each pre synaptic neuron can release how many types of neurotransmittersPost synaptic neurons may respond to one or many different neurotransmitters
1Many
Addition of stimuli of both excitatory and inhibitory on decision on whether to fire action potential or not
Summation
Excitatory Neuro transmitters cause post synaptic depolarization or
Excitatory post synaptic potentials (EPSP)
Inhibitory neurotransmitters cause
Inhibitory post synaptic potentials
A form of summation where presynaptic neuron fires ap so fast that esps and isps pile on each otherIf enough esps=apIf isps=hyperpolarized
Temporal summation
Form of summation where both epsp and ipsp from all synapses on post synaptic membrane summed at any given moment
Spatial summation
How can pre synaptic neuron increase intensity of signal?
Increase ap frequencyAdds up thru temporal summation and increases response
True or false: Magnitude of depolarization doesn’t change
True
True or false: a neuron can only release one type of Neuro transmitter and can’t change this
True
T or f:Speed of propagation doesn’t change when considering multiple action potentials
True
Receiving information is what part of the nervous system
Carried out by what?
Sensory
PNS
Processing information in the nervous system is the what function
Carried out by what?
Integrative
CNS
Acting out part of the nervous system is the
Carried out by what part?
Motor
PNS
Carry info from nervous system to organs
Motor neurons
Act upon information from motor neurons
Effectors
What are the 2 types of effectors?
Muscles and Glands
Motor neurons that activate effectors are called what neurons
Efferent
Sensory neurons that carry info toward CNS are called what neurons
Afferent
Afferent neurons are what type of neurons
Sensory Neurons
Simplest example of nervous system activity is the
reflex
Sensory neuron transmits AP to a synapse with a motor neuron in the spinal cords which causes action to occur
Reflex
Sensory neuron transmits information to what in the spinal cord?
Motor neuron cell body
A reflex involving 2 neurons and 1 synapse
Monosynaptic Reflex Arc
A short neuron that forms an inhibitory synapse with a motor neuron innervating the hamstring muscle for example (so it relaxes while the quads contracts)
Inhibitory Interneuron
In a reflex, concurrent relaxation of the hamstring and contraction of the quadriceps is an example of
Reciprocal Inhibition
The peripheral nervous system can be divided into what parts
Somatic and Autonomic
Portion of PNS involved with conscious sensation and deliberate voluntary movement of skeletal muscle
Somatic
Portion of PNS concerned with digestion, metabolism, circulation, perspiration, and other involuntary processes
Autonomic
Efferent portions of autonomic division of PNS are called
Sympathetic and Parasympathetic
Parasympathetic effects on glands and motility
Stimulation
Parasympathetic effects on sphincters
Relaxation
Parasympathetic effects on bladder
Contraction
Parasympathetic effects of bronchial smooth muscle
Constriction (closes airways)
Parasympathetic effects on HR and Contractility
Decreased
Parasympathetic effects on pupil and lens
Dilation
Good Clear vision
Parasympathetic effects on genitals
Erection/Lubrication
Sympathetic Effects on glands and motility in digestive system
Inhibition
Sympathetic Effects on bladder
Relaxation
Sympathetic Effects on HR and contractility
Increased
Sympathetic Effects on skin
Sweating and vasoconstriction
Blushing
Sympathetic Effects on Adrenal Medulla
Epinephrine release
Sympathetic Effects on genitals
Ejaculation/Orgasm
The 2 main anatomical division of the nervous system
CNS and PNS
2 main components of CNS
Brain and Spinal Chord
PNS parts
Axons Dentrites and Cell bodies
Most neuronal cell bodies (Nuclei) or found where
CNS
Bundles of soma or cell bodies in the CNS
Nuclei
Somas located in the PNS
Ganglia
The 3 subdivision of the brain
- Hindbrain (Rhombencephalon)
- Midbrain (Mesencephalon)
- Forebrain
(Prosencephalon)
The entire CNS (Brain and Spinal Cord) floats in what
CSF
Simple spinal reflexes are governed by what part of CNS
Spinal Cord
Primitive processes like walking, urination, and sex organ function is govern by what part of CNS
Spinal Cord
3 Parts of the hindbrain (Rhombencephalon)
Medulla, Pons, Cerebellum
Located below the pons
Medulla
Part of the hindbrain that regulates vital autonomic functions such as BP and digestion and vomiting
Medulla
Part of the hindbrain that contain respiratory rhythmicity centers
Medulla
Part of Hindbrain located below Midbrain
Pons
Located above the medulla
Pons
Connection between brain stem and cerebellum
Pons
Plays role in balance and antigravity posture
Controls some autonomic functions/Coordinates movements
Pons
Part of Hindbrain located behind pons
Cerebellum
Poor hand eye coordination and balance could be because of damage to what part of the brain
Cerebellum
2 Parts of the hindbrain that receive information from the vestibular apparatus in the inner ear
Pons and cerebellum
Pons and cerebellum receive info from what part of the inner ear
Vestibular apparatus
What part of inner ear monitors acceleration and position relative to gravity
Vestibular apparatus
Relay for visual and auditory information
Midbrain (mesencephalon)
Contains much of the reticular activating system (RAS) (responsible for arousal and wakefulness)
Midbrain (mesencephalon)